Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | DHFR | P00374 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.40 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL64640 | 0.83 | MAPK1 (0.65) | MAPK1SMN1; SMN2L3MBTL1KDM4EGAA | |
| SCHEMBL29552438 | 0.83 | MAPK1 (0.65) | MAPK1SMN1; SMN2L3MBTL1KDM4EGAA | |
| SCHEMBL29776105 | 0.81 | MAPK1 (0.62) | MAPK1SMN1; SMN2L3MBTL1KDM4EGAA | |
| SCHEMBL20241211 | 0.81 | MAPK1 (0.62) | MAPK1SMN1; SMN2L3MBTL1KDM4EGAA | |
| SCHEMBL6984646 | 0.81 | RAB9A (0.59) | KDM4ENAPRTRAB9APOLBDHFR | |
| SCHEMBL38659193 | 0.80 | KDM4E (0.50) | MAPK1SMN1; SMN2L3MBTL1KDM4EGAA | |
| SCHEMBL2952147 | 0.80 | KDM4E (0.50) | MAPK1SMN1; SMN2L3MBTL1KDM4EGAA | |
| SCHEMBL1945357 | 0.78 | KDM4E (0.42) | MAPK1SMN1; SMN2L3MBTL1KDM4EGAA | |
| SCHEMBL117753 | 0.73 | KDM4E (0.41) | MAPK1SMN1; SMN2L3MBTL1KDM4ERAB9A | |
| SCHEMBL23796888 | 0.72 | NAPRT (0.55) | MAPK1SMN1; SMN2L3MBTL1KDM4EGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1037886-A1 | TRIAZINE ANGIOGENESIS INHIBITORS | Abbott Laboratories (US) | 2000-09-27 | — | — | EP | disclosed |
| WO-1999031088-A1 | TRIAZINE ANGIOGENESIS INHIBITORS | ABBOTT LABORATORIES (US) | 1999-06-24 | — | — | WO | disclosed |