SCHEMBL8153455

SCHEMBL8153455

Nc1cc(C(F)(F)F)cc(Oc2cc(Oc3cc(C(F)(F)F)cc(N)c3C(F)(F)F)cc(C(F)(F)F)c2)c1C(F)(F)F

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 5/20 0.44
L3MBTL1 Q9Y468 4/20 0.44
NPSR1 Q6W5P4 1/20 0.44
RAB9A P51151 1/20 0.44
LMNA P02545 1/20 0.41
ATM Q13315 1/20 0.41
PTPN5 P54829 2/20 0.36
ALDH1A1 P00352 5/20 0.34
KDM4E B2RXH2 3/20 0.33
SMN1; SMN2 Q16637 1/20 0.33
HTR2A P28223 1/20 0.33
SLC6A4 P31645 1/20 0.33
KCNH2 Q12809 1/20 0.33
CFTR P13569 1/20 0.32
HSD17B10 Q99714 2/20 0.32
PKM P14618 1/20 0.32
HPGD P15428 1/20 0.32
IDO1 P14902 2/20 0.32
MEN1 O00255 1/20 0.32
USP2 O75604 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8147336 0.89 L3MBTL1 (0.55) MAPTL3MBTL1NPSR1RAB9ALMNA
SCHEMBL8146241 0.88 MAPT (0.58) MAPTL3MBTL1NPSR1RAB9ALMNA
SCHEMBL8152693 0.85 L3MBTL1 (0.39) MAPTL3MBTL1NPSR1RAB9ALMNA
SCHEMBL8152725 0.81 L3MBTL1 (0.48) MAPTL3MBTL1NPSR1RAB9ALMNA
SCHEMBL8143447 0.80 L3MBTL1 (0.47) MAPTL3MBTL1NPSR1RAB9ALMNA
SCHEMBL8145238 0.80 L3MBTL1 (0.43) MAPTL3MBTL1NPSR1RAB9ALMNA
SCHEMBL8150893 0.79 L3MBTL1 (0.36) MAPTL3MBTL1NPSR1RAB9ALMNA
SCHEMBL8152775 0.79 L3MBTL1 (0.42) MAPTL3MBTL1NPSR1RAB9ALMNA
SCHEMBL8151365 0.79 L3MBTL1 (0.46) MAPTL3MBTL1NPSR1RAB9ALMNA
SCHEMBL8150082 0.78 L3MBTL1 (0.35) MAPTL3MBTL1NPSR1RAB9ALMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6103860-A LOW DIELECTRIC CONSTANT, EXCELLENT TRANSPARENCY, LOW HYGROSCOPICITY AND EXCELLENT PROCESSABILITY; SUBSTRATE FOR AN OPTICAL DISK, A PICK-UP LENS, A PLASTIC SUBSTRATE FOR A LIQUID CELL AND A PRISM MITSUI CHEMICALS, INC. (JP) 2000-08-15 US disclosed
US-5990261-A Organic optical component MITSUI CHEMICALS, INC. (JP) 1999-11-23 US disclosed
EP-0826717-A1 An organic optical component MITSUI TOATSU CHEMICALS, INCORPORATED (JP) 1998-03-04 EP disclosed