SCHEMBL8150893

SCHEMBL8150893

Nc1cc(C(F)(F)F)cc(Oc2cc(Oc3cc(C(F)(F)F)cc(N)c3C(F)(F)F)c(C(F)(F)F)cc2C(F)(F)F)c1C(F)(F)F

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 4/20 0.36
RAB9A P51151 1/20 0.36
PTPN5 P54829 2/20 0.34
ALDH1A1 P00352 4/20 0.33
MAPT P10636 3/20 0.33
KDM4E B2RXH2 2/20 0.33
HSD17B10 Q99714 2/20 0.33
MEN1 O00255 1/20 0.33
USP2 O75604 1/20 0.33
HSP90AA1 P07900 1/20 0.33
HSP90AB1 P08238 1/20 0.33
THRB P10828 1/20 0.33
G6PD P11413 1/20 0.33
ALOX15 P16050 1/20 0.33
CASP1 P29466 1/20 0.33
KMT2A Q03164 1/20 0.33
LMNA P02545 1/20 0.33
ATM Q13315 1/20 0.33
NPSR1 Q6W5P4 1/20 0.33
CFTR P13569 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8143447 0.86 L3MBTL1 (0.47) L3MBTL1RAB9AALDH1A1MAPTKDM4E
SCHEMBL8152693 0.86 L3MBTL1 (0.39) L3MBTL1RAB9APTPN5ALDH1A1MAPT
SCHEMBL8145238 0.83 L3MBTL1 (0.43) L3MBTL1RAB9AMAPTKDM4ELMNA
SCHEMBL8147355 0.80 L3MBTL1 (0.38) L3MBTL1RAB9APTPN5ALDH1A1MAPT
SCHEMBL8152775 0.80 L3MBTL1 (0.42) L3MBTL1RAB9APTPN5ALDH1A1MAPT
SCHEMBL8152225 0.80 AR (0.33) L3MBTL1ALDH1A1MAPTKDM4EHSD17B10
SCHEMBL8151840 0.80 L3MBTL1 (0.33) L3MBTL1RAB9APTPN5ALDH1A1MAPT
SCHEMBL8147336 0.79 L3MBTL1 (0.55) L3MBTL1RAB9APTPN5ALDH1A1MAPT
SCHEMBL8153455 0.79 MAPT (0.44) L3MBTL1RAB9APTPN5ALDH1A1MAPT
SCHEMBL8145754 0.77 CYP1A2 (0.35) L3MBTL1ALDH1A1MAPTKDM4EHSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6103860-A LOW DIELECTRIC CONSTANT, EXCELLENT TRANSPARENCY, LOW HYGROSCOPICITY AND EXCELLENT PROCESSABILITY; SUBSTRATE FOR AN OPTICAL DISK, A PICK-UP LENS, A PLASTIC SUBSTRATE FOR A LIQUID CELL AND A PRISM MITSUI CHEMICALS, INC. (JP) 2000-08-15 US disclosed
US-5990261-A Organic optical component MITSUI CHEMICALS, INC. (JP) 1999-11-23 US disclosed
EP-0826717-A1 An organic optical component MITSUI TOATSU CHEMICALS, INCORPORATED (JP) 1998-03-04 EP disclosed