SCHEMBL8153647

SCHEMBL8153647

COc1cc(Cc2ccc(O)cc2)c(O)c(Cc2cc(Cc3cc(OC)cc(Cc4ccc(O)cc4)c3O)c(O)c(C3CCCCC3)c2)c1

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PTGDR2 Q9Y5Y4 1/20 0.37
CALM1 P0DP23 3/20 0.37
NUDT1 P36639 1/20 0.37
BACE1 P56817 1/20 0.37
CYP26A1 O43174 2/20 0.35
CYP19A1 P11511 2/20 0.34
ESR1 P03372 1/20 0.34
ESR2 Q92731 1/20 0.34
CYP24A1 Q07973 1/20 0.33
MIF P14174 1/20 0.33
EPHX2 P34913 1/20 0.33
EDNRA P25101 1/20 0.33
TUBB4A P04350 1/20 0.33
TUBB P07437 1/20 0.33
TUBA3C P0DPH7 1/20 0.33
TUBA1B P68363 1/20 0.33
TUBA4A P68366 1/20 0.33
TUBB4B P68371 1/20 0.33
TUBB3 Q13509 1/20 0.33
TUBB2A Q13885 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14463141 0.92 CALM1 (0.40) PTGDR2CALM1NUDT1BACE1CYP26A1
SCHEMBL8149573 0.89 NUDT1 (0.36) NUDT1BACE1
SCHEMBL8141767 0.88 NUDT1 (0.40) NUDT1BACE1ESR1ESR2
SCHEMBL8154645 0.87 CYP19A1 (0.39) PTGDR2CALM1NUDT1BACE1CYP19A1
SCHEMBL2385696 0.87 NUDT1 (0.39) PTGDR2NUDT1BACE1ESR1ESR2
SCHEMBL8151074 0.87 CYP26A1 (0.37) CALM1CYP26A1CYP19A1ESR1ESR2
SCHEMBL4061548 0.86 NUDT1 (0.44) NUDT1BACE1ESR1ESR2
SCHEMBL8142256 0.85 NUDT1 (0.40) NUDT1BACE1ESR1ESR2EPHX2
SCHEMBL8142469 0.84 NUDT1 (0.39) NUDT1BACE1ESR1ESR2
SCHEMBL8142482 0.82 NUDT1 (0.40) NUDT1BACE1ESR1ESR2EPHX2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6127087-A COMPOSITION COMPRISING ALKALI-SOLUBLE RESIN, SPECIFIED QUINONEDIAZIDE COMPOUND TOKYO OHKA KOGYO CO., LTD. (JP) 2000-10-03 US disclosed
US-6106994-A ESTERIFYING A POLYPHENOL COMPOUND AND NAPHTHOQUINONE-1,2-DIAZIDESULFONYL HALIDE IN THE PRESENCE OF FOR EXAMPLE MONOMETHYLDICYCLOHEXYLAMINE, AND POSITIVE PHOTOSENSITIVE COMPOSITION CONTAINS RESULTANT ESTER TOKYO OHKA KOGYO CO., LTD. (JP) 2000-08-22 US disclosed