SCHEMBL8154157

SCHEMBL8154157

CC[O-].c1ccc([Al+]c2ccccc2)cc1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TP53 P04637 1/20 0.39
ALDH1A1 P00352 1/20 0.36
CES2 O00748 2/20 0.34
CES1 P23141 2/20 0.34
PSIP1 O75475 1/20 0.33
LMNA P02545 2/20 0.32
TSHR P16473 1/20 0.32
ALOX12 P18054 1/20 0.32
ACHE P22303 1/20 0.32
CHRNA7 P36544 2/20 0.32
CHRNA10 Q9GZZ6 1/20 0.32
CHRNA9 Q9UGM1 1/20 0.32
ELANE P08246 1/20 0.31
CHRNB2 P17787 1/20 0.31
CHRNB4 P30926 1/20 0.31
CHRNA3 P32297 1/20 0.31
CHRNA4 P43681 1/20 0.31
ATM Q13315 1/20 0.31
KCNN4 O15554 1/20 0.31
HSD17B10 Q99714 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8511868 0.85 TSHR (0.37) TP53ALDH1A1LMNATSHRALOX12
SCHEMBL8512791 0.79 TSHR (0.37) TP53ALDH1A1LMNATSHRALOX12
SCHEMBL148446 0.78 ALDH1A1 (0.39) ALDH1A1LMNATSHRALOX12ACHE
Hydrochloric Acid SCHEMBL150126 0.78 ALDH1A1 (0.39) ALDH1A1LMNATSHRALOX12ACHE
SCHEMBL1228647 0.78 ALDH1A1 (0.39) ALDH1A1LMNATSHRALOX12ACHE
Fluoride Ion SCHEMBL1538989 0.78 ALDH1A1 (0.47) ALDH1A1LMNATSHRALOX12ACHE
Bromide SCHEMBL1538842 0.78 ALDH1A1 (0.39) ALDH1A1LMNATSHRALOX12ACHE
Iodide SCHEMBL2166396 0.78 ALDH1A1 (0.39) ALDH1A1LMNATSHRALOX12ACHE
SCHEMBL8515352 0.77 TSHR (0.35) TP53ALDH1A1LMNATSHRALOX12
SCHEMBL11726645 0.76 ACHE (0.42) ALDH1A1ACHEELANEATMHSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1061090-A1 Reduction of oligomer and gel formation in polyolefins UNION CARBIDE CHEMICALS & PLASTICS TECHNOLOGY CORPORATION (US) 2000-12-20 EP disclosed
EP-0630910-A1 Use of Lewis Bases for activity reduction in metallocene catalyzed olefin polymerization reactions UNION CARBIDE CHEMICALS & PLASTICS TECHNOLOGY CORPORATION (US) 1994-12-28 EP disclosed
US-4028429-A ORGANONICKEL-ALUMINUM-AMINEPHOSPHINE COMPLEX E. I. DU PONT DE NEMOURS AND COMPANY (US) 1977-06-07 US disclosed
US-4025570-A REACTION OF ETHYLENE WITH 1,3-DIENE; CATALYST OF NICKEL, HYDROCARBYLALUMINUM HALIDE, AND ARYL PHOSPHINITE E. I. DU PONT DE NEMOURS AND COMPANY (US) 1977-05-24 US disclosed