SCHEMBL8154167

SCHEMBL8154167

COc1cc(C(C)c2cc(OC)c(Oc3ccc(N)cc3)c(OC)c2)cc(OC)c1Oc1ccc(N)cc1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 3/20 0.45
TDP1 Q9NUW8 4/20 0.44
MAPK1 P28482 2/20 0.44
CYP19A1 P11511 5/20 0.42
NQO2 P16083 1/20 0.42
ALDH1A1 P00352 7/20 0.42
CYP3A4 P08684 2/20 0.42
TSHR P16473 1/20 0.42
TEAD4 Q15561 1/20 0.40
NPBWR1 P48145 1/20 0.39
MCHR1 Q99705 1/20 0.39
MAPT P10636 3/20 0.39
POLB P06746 1/20 0.39
MEN1 O00255 1/20 0.39
MITF O75030 1/20 0.39
GAA P10253 1/20 0.39
GFER P55789 1/20 0.39
KMT2A Q03164 1/20 0.39
NLRP1 Q9C000 1/20 0.39
NOD2 Q9HC29 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12635145 0.85 CYP19A1 (0.43) SMN1; SMN2TDP1MAPK1CYP19A1NQO2
SCHEMBL8151816 0.82 SMN1; SMN2 (0.44) SMN1; SMN2TDP1MAPK1CYP19A1ALDH1A1
SCHEMBL2514220 0.79 ALDH1A1 (0.48) SMN1; SMN2TDP1MAPK1ALDH1A1CYP3A4
SCHEMBL8157862 0.78 CYP19A1 (0.56) SMN1; SMN2TDP1MAPK1CYP19A1NQO2
SCHEMBL8158114 0.78 NPBWR1 (0.46) SMN1; SMN2TDP1MAPK1ALDH1A1CYP3A4
SCHEMBL8158091 0.78 MAPT (0.46) SMN1; SMN2TDP1MAPK1ALDH1A1CYP3A4
SCHEMBL8905674 0.78 SMN1; SMN2 (0.46) SMN1; SMN2TDP1MAPK1CYP19A1NQO2
SCHEMBL8578395 0.77 PTGS2 (0.56) SMN1; SMN2TDP1MAPK1CYP19A1NQO2
SCHEMBL8153663 0.77 ALDH1A1 (0.49) SMN1; SMN2TDP1MAPK1CYP19A1NQO2
SCHEMBL12574076 0.76 ALDH1A1 (0.36) SMN1; SMN2TDP1MAPK1CYP19A1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0700532-B1 ALIGNMENT LAYER FOR LIQUID CRYSTALS AVENTIS RES & TECH GMBH & CO (DE) 2000-03-29 EP disclosed
EP-0604885-B1 Liquid crystal display device HOECHST AG (DE) 1997-12-10 EP disclosed
US-5656340-A Liquid crystal display device HOECHST AKTIENGESELLSCHAFT (DE) 1997-08-12 US disclosed
EP-0708149-A1 Alignment layer material for liquid crystal display devices HOECHST AKTIENGESELLSCHAFT (DE) 1996-04-24 EP disclosed
EP-0700532-A1 ALIGNMENT LAYER FOR LIQUID CRYSTALS HOECHST AKTIENGESELLSCHAFT (DE) 1996-03-13 EP disclosed
EP-0690334-A2 Liquid crystal display device HOECHST AKTIENGESELLSCHAFT (DE) 1996-01-03 EP disclosed
US-5437813-A A thin alignment layer comprising an aromatic polyamide-polysiloxane block homo- or copolymer with different content of polysiloxane to adjust optical pretilt angle HOECHST AKTIENGESELLSCHAFT (DE) 1995-08-01 US disclosed
EP-0336536-B1 Organic-solvent soluble polyimide and production thereof HITACHI CHEMICAL CO LTD (JP) 1995-06-28 EP disclosed
WO-1994028458-A1 ALIGNMENT LAYER FOR LIQUID CRYSTALS HOECHST AKTIENGESELLSCHAFT (DE) 1994-12-08 WO disclosed
EP-0604885-A1 Liquid crystal display device HOECHST AKTIENGESELLSCHAFT (DE) 1994-07-06 EP disclosed
US-5037862-A Excellent mechanical stability in printing HITACHI CHEMICAL COMPANY, LTD. (JP) 1991-08-06 US disclosed
US-4954612-A ORIENTATION CONTROL FOR LIQUID CRYSTAL DISPLAY HITACHI CHEMICAL CO., LTD. (JP) 1990-09-04 US disclosed
EP-0336536-A2 Organic-solvent soluble polyimide and production thereof Hitachi Chemical Co., Ltd. (JP) 1989-10-11 EP disclosed
US-4791157-A REACTING TRIMELLITIC ACID WITH AROMATIC DIAMINE WITH ETHER GROUPS HITACHI CHEMICAL CO. (JP) 1988-12-13 US disclosed