Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 4/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | MAOA | P21397 | 1/20 | 0.45 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.45 |
| ▸ | CES2 | O00748 | 1/20 | 0.45 |
| ▸ | CES1 | P23141 | 1/20 | 0.45 |
| ▸ | ACHE | P22303 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8160045 | 0.86 | METAP1 (0.52) | RAB9AMAPK1NPC1ALDH1A1 | |
| SCHEMBL11857136 | 0.84 | MAPT (0.59) | KMT2AMAPTKDM4EMEN1L3MBTL1 | |
| SCHEMBL23618751 | 0.83 | MAPT (0.70) | KMT2AMAPTKDM4EMEN1L3MBTL1 | |
| SCHEMBL1000380 | 0.77 | ACHE (0.51) | KMT2AMAPTKDM4EMEN1L3MBTL1 | |
| SCHEMBL6970354 | 0.77 | MAPT (0.68) | KMT2AMAPTRAB9AMAPK1NPC1 | |
| SCHEMBL29476747 | 0.77 | ACHE (0.51) | KMT2AMAPTKDM4EMEN1L3MBTL1 | |
| SCHEMBL5217220 | 0.75 | MAPK1 (0.53) | MAPTRAB9AMAPK1NPC1SMN1; SMN2 | |
| SCHEMBL856747 | 0.75 | ACHE (0.56) | KMT2AMAPTKDM4EMEN1L3MBTL1 | |
| SCHEMBL9148955 | 0.75 | CYP19A1 (0.59) | MAPTKDM4ERAB9AMAPK1NPC1 | |
| SCHEMBL9247422 | 0.74 | MAPK1 (0.46) | KMT2ARAB9AMAPK1NPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6107346-A | ADMINISTERING AND AROMATIC KETONE COMPOUND | ELI LILLY AND COMPANY (US) | 2000-08-22 | — | — | US | disclosed |
| EP-0897903-A2 | Ketone-derivatives of indene, dihydronaphthalene or naphthalene compounds for the treatment of hyperlipidemia | ELI LILLY AND COMPANY (US) | 1999-02-24 | — | — | EP | disclosed |
| WO-1999007360-A1 | COMPOUNDS AND USES THEREOF | ELI LILLY AND COMPANY (US) | 1999-02-18 | — | — | WO | disclosed |
| US-4075223-A | NONSTEROIDAL | ELI LILLY AND COMPANY (US) | 1978-02-21 | — | — | US | disclosed |
| US-4017546-A | AROYL PHENYL INDENES AND AROYL PHENYL NAPHTHALENES | ELI LILLY AND COMPANY (US) | 1977-04-12 | — | — | US | disclosed |