Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.42 |
| ▸ | GCGR | P47871 | 1/20 | 0.41 |
| ▸ | TNKS | O95271 | 1/20 | 0.40 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.40 |
| ▸ | CTSK | P43235 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | ADAM10 | O14672 | 1/20 | 0.39 |
| ▸ | MMP2 | P08253 | 1/20 | 0.39 |
| ▸ | MMP3 | P08254 | 1/20 | 0.39 |
| ▸ | MMP7 | P09237 | 1/20 | 0.39 |
| ▸ | MMP9 | P14780 | 1/20 | 0.39 |
| ▸ | MMP13 | P45452 | 1/20 | 0.39 |
| ▸ | MMP14 | P50281 | 1/20 | 0.39 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.39 |
| ▸ | FLT3 | P36888 | 1/20 | 0.39 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.39 |
| ▸ | MERTK | Q12866 | 1/20 | 0.39 |
| ▸ | GAS6 | Q14393 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14943761 | 0.89 | LMNA (0.45) | LMNASCN9AGCGRTNKSPARP1 | |
| SCHEMBL12481355 | 0.88 | LMNA (0.44) | LMNASCN9AGCGRTNKSPARP1 | |
| SCHEMBL12401674 | 0.87 | LMNA (0.43) | LMNASCN9AGCGRTNKSPARP1 | |
| SCHEMBL15338722 | 0.84 | SCN9A (0.46) | LMNASCN9AGCGRTNKSPARP1 | |
| SCHEMBL8132918 | 0.78 | LMNA (0.48) | LMNAMAPK1NAMPTKLKB1 | |
| SCHEMBL12413652 | 0.76 | KDM4E (0.46) | LMNACTSKMAPK1NAMPTKLKB1 | |
| SCHEMBL17469086 | 0.74 | LMNA (0.55) | LMNASCN9ATNKSPARP1TNKS2 | |
| SCHEMBL23775645 | 0.73 | SCN9A (0.38) | LMNASCN9ATNKSPARP1TNKS2 | |
| SCHEMBL23755092 | 0.73 | ANPEP (0.42) | LMNASCN9ATNKSPARP1TNKS2 | |
| SCHEMBL14438268 | 0.71 | NOTUM (0.49) | LMNAPARP1MAPK1CCNE1CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008106058-A2 | INHIBITORS OF SERINE PROTEASES | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2008-09-04 | — | — | WO | disclosed |