SCHEMBL8156316

SCHEMBL8156316

Ic1ccc2c(cnc3cc(I)ccc32)c1

nearest known ligand 0.42

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 2/20 0.42
GPR3 P46089 1/20 0.42
NOS1 P29475 1/20 0.38
APP P05067 5/20 0.36
PARP1 P09874 1/20 0.34
TOP2A P11388 1/20 0.34
GAK O14976 1/20 0.34
MAPT P10636 2/20 0.33
PRNP P04156 1/20 0.32
ALDH1A1 P00352 1/20 0.31
HTT P42858 1/20 0.31
NCOA1 Q15788 1/20 0.31
NCOA3 Q9Y6Q9 1/20 0.31
SCN9A Q15858 1/20 0.30
EGFR P00533 1/20 0.30
PDPK1 O15530 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22062340 0.78 KDM4E (0.47) KDM4EGPR3MAPTALDH1A1HTT
SCHEMBL18848507 0.74 ESR2 (0.41) NOS1APPPARP1MAPTEGFR
SCHEMBL23190280 0.72 NOS1 (0.35) KDM4EGPR3NOS1APPPARP1
SCHEMBL14359424 0.72 NOS1 (0.36) NOS1MAPT
SCHEMBL1419169 0.71 NOS1 (0.39) NOS1APPMAPTALDH1A1
SCHEMBL18848508 0.71 NOS1 (0.42) NOS1APPPARP1MAPTALDH1A1
SCHEMBL10259398 0.71 NQO2 (0.47) KDM4EGPR3PARP1MAPTALDH1A1
SCHEMBL9207870 0.71 TLR9 (0.47) KDM4EGPR3MAPTALDH1A1HTT
SCHEMBL28778104 0.71 PTGES (0.45) KDM4EGPR3HTT
SCHEMBL20019436 0.71 GPR3 (0.62) KDM4EGPR3PARP1TOP2AEGFR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-2000327664-A HOLE-TRANSPORTING COMPOUND AND ORGANIC THIN FILM LUMINESCENT ELEMENT PRODUCED BY USING THE COMPOUND TOPPAN PRINTING CO LTD 2000-11-28 JP disclosed