Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 13/20 | 0.52 |
| ▸ | ERBB2 | P04626 | 7/20 | 0.52 |
| ▸ | ERBB4 | Q15303 | 2/20 | 0.52 |
| ▸ | FYN | P06241 | 5/20 | 0.51 |
| ▸ | SRC | P12931 | 5/20 | 0.51 |
| ▸ | RAF1 | P04049 | 1/20 | 0.47 |
| ▸ | BRAF | P15056 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.46 |
| ▸ | BLK | P51451 | 1/20 | 0.46 |
| ▸ | BMX | P51813 | 1/20 | 0.46 |
| ▸ | JAK3 | P52333 | 1/20 | 0.46 |
| ▸ | BTK | Q06187 | 1/20 | 0.46 |
| ▸ | VCP | P55072 | 1/20 | 0.45 |
| ▸ | FBP1 | P09467 | 1/20 | 0.44 |
| ▸ | EPHB2 | P29323 | 1/20 | 0.44 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8486257 | 0.93 | RAF1 (0.55) | EGFRERBB2ERBB4FYNSRC | |
| SCHEMBL8150558 | 0.79 | EGFR (0.76) | EGFRERBB2ERBB4FYNSRC | |
| SCHEMBL29687408 | 0.79 | MMP12 (0.41) | MAPT | |
| SCHEMBL4191995 | 0.78 | EGFR (0.69) | EGFRERBB2ERBB4FYNSRC | |
| SCHEMBL7128555 | 0.78 | EGFR (0.47) | EGFRERBB2ERBB4FYNSRC | |
| SCHEMBL7128556 | 0.77 | EGFR (0.47) | EGFRERBB2ERBB4FYNSRC | |
| SCHEMBL8154615 | 0.76 | EGFR (0.77) | EGFRERBB2ERBB4FYNSRC | |
| SCHEMBL22200858 | 0.72 | EGFR (0.61) | EGFRERBB2ERBB4FYNSRC | |
| SCHEMBL7126655 | 0.71 | FBP1 (0.46) | EGFRERBB2ERBB4RAF1BRAF | |
| SCHEMBL8149145 | 0.71 | EGFR (0.66) | EGFRERBB2ERBB4FYNSRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1999006396-A1 | IRREVERSIBLE BICYCLIC INHIBITORS OF TYROSINE KINASES | WARNER-LAMBERT COMPANY (US) | 1999-02-11 | — | — | WO | claimed |