Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.38 |
| ▸ | GAA | P10253 | 5/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.38 |
| ▸ | HPGD | P15428 | 4/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.38 |
| ▸ | USP2 | O75604 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | RAF1 | P04049 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | BRS3 | P32247 | 2/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | CASP1 | P29466 | 1/20 | 0.35 |
| ▸ | CASP7 | P55210 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | CFTR | P13569 | 3/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6181801 | 0.77 | GAA (0.37) | KDM4EGAAALDH1A1HSD17B10HPGD | |
| SCHEMBL7813278 | 0.77 | SMN1; SMN2 (0.41) | KDM4EALDH1A1HSD17B10HPGDMAPT | |
| SCHEMBL3220088 | 0.76 | MAPK14 (0.55) | KDM4EGAAALDH1A1HSD17B10HPGD | |
| SCHEMBL5440710 | 0.69 | ALDH1A1 (0.35) | KDM4EGAAALDH1A1HSD17B10HPGD | |
| SCHEMBL5775175 | 0.62 | ALDH1A1 (0.46) | KDM4EGAAALDH1A1HSD17B10HPGD | |
| SCHEMBL7812401 | 0.62 | MAPK14 (0.48) | KDM4EGAAALDH1A1HSD17B10HPGD | |
| SCHEMBL20568972 | 0.62 | GAA (0.45) | KDM4EGAAALDH1A1HSD17B10HPGD | |
| SCHEMBL21643603 | 0.62 | PDPK1 (0.60) | KDM4EGAAALDH1A1HSD17B10HPGD | |
| SCHEMBL7634346 | 0.62 | CYP1A2 (0.55) | KDM4EGAAALDH1A1HSD17B10HPGD | |
| Hydrochloric Acid SCHEMBL7485321 | 0.61 | CYP1A2 (0.53) | KDM4EGAAALDH1A1HSD17B10HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1019040-A4 | INHIBITION OF p38 KINASE ACTIVITY BY ARYL UREAS | BAYER AG (US) | 2000-10-04 | — | — | EP | disclosed |
| EP-1019040-A1 | INHIBITION OF p38 KINASE ACTIVITY BY ARYL UREAS | Bayer Corporation (US) | 2000-07-19 | — | — | EP | disclosed |
| WO-1998052558-A1 | INHIBITION OF p38 KINASE ACTIVITY BY ARYL UREAS | BAYER CORPORATION (US) | 1998-11-26 | — | — | WO | disclosed |