SCHEMBL8157734

SCHEMBL8157734

C(=C[Si](c1ccccc1)(c1ccccc1)c1ccccc1)c1ccccc1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOB P27338 3/20 0.48
ALDH1A1 P00352 4/20 0.45
MEN1 O00255 2/20 0.45
KMT2A Q03164 2/20 0.45
KDM4E B2RXH2 2/20 0.45
HPGD P15428 2/20 0.45
NFE2L2 Q16236 2/20 0.41
CYP19A1 P11511 2/20 0.41
MAOA P21397 2/20 0.41
CYP11B1 P15538 1/20 0.41
CYP11B2 P19099 1/20 0.41
RELA Q04206 1/20 0.41
LMNA P02545 2/20 0.41
TRPA1 O75762 1/20 0.41
ALOX5 P09917 1/20 0.41
MAPK1 P28482 1/20 0.41
PDGFRB P09619 1/20 0.39
PDGFRA P16234 1/20 0.39
HDAC3 O15379 1/20 0.39
TNKS O95271 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7748547 0.89 CA1 (0.44) MAOBALDH1A1MEN1KMT2AKDM4E
SCHEMBL7748544 0.89 CA1 (0.44) MAOBALDH1A1MEN1KMT2AKDM4E
SCHEMBL13020941 0.85 CYP19A1 (0.59) MAOBALDH1A1MEN1KMT2AKDM4E
SCHEMBL30790665 0.82 NFE2L2 (0.66) NFE2L2RELAMAPK1CYP1A2CYP2D6
SCHEMBL30790664 0.82 HSD17B3 (0.49) MAOBALDH1A1MAOACYP2D6MAPT
SCHEMBL29141684 0.82 MAOB (0.50) MAOBALDH1A1MEN1KMT2AHPGD
SCHEMBL29141683 0.82 MAOB (0.50) MAOBALDH1A1MEN1KMT2AHPGD
SCHEMBL30790666 0.82 MAOB (0.50) MAOBALDH1A1MEN1KMT2AHPGD
SCHEMBL15087173 0.82 RELA (0.41) ALDH1A1MEN1KMT2AKDM4EHPGD
SCHEMBL29141716 0.82 NFE2L2 (0.66) NFE2L2RELAMAPK1CYP1A2CYP2D6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6080819-A Blends of olefin polymers and syndiotactic vinyl polymers BOREALIS AG (AT) 2000-06-27 US claimed
US-6080819-A Blends of olefin polymers and syndiotactic vinyl polymers BOREALIS AG (AT) 2000-06-27 US disclosed
EP-0884356-A2 Blends of polyolefins and syndiotactic vinyl polymeres PCD Polymere AG (AT) 1998-12-16 EP disclosed