Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.32 |
| ▸ | CNR2 | P34972 | 3/20 | 0.31 |
| ▸ | CNR1 | P21554 | 2/20 | 0.31 |
| ▸ | HTT | P42858 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | CRHBP | P24387 | 1/20 | 0.31 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | RORC | P51449 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8149715 | 0.87 | IDO1 (0.36) | MEN1KMT2AKDM4EALDH1A1TSHR | |
| SCHEMBL8143240 | 0.86 | HTR3A (0.36) | MEN1KMT2AKDM4EALDH1A1HSD17B10 | |
| SCHEMBL8152609 | 0.85 | CTNNB1 (0.34) | KMT2AKDM4EALDH1A1TSHRHTT | |
| SCHEMBL8155928 | 0.82 | KDM4E (0.33) | MEN1KMT2AKDM4EALDH1A1TSHR | |
| SCHEMBL8149948 | 0.80 | HPGD (0.34) | MEN1KMT2AKDM4EALDH1A1HTT | |
| SCHEMBL8160781 | 0.79 | MEN1 (0.44) | MEN1KMT2AKDM4EALDH1A1TSHR | |
| SCHEMBL8155111 | 0.78 | ELANE (0.41) | MEN1KMT2A | |
| SCHEMBL8153984 | 0.78 | SMN1; SMN2 (0.35) | MEN1KMT2AKDM4EALDH1A1HTT | |
| SCHEMBL8150532 | 0.77 | CNR2 (0.34) | MEN1KMT2AKDM4EALDH1A1TSHR | |
| SCHEMBL8144738 | 0.76 | NPC1 (0.38) | MEN1KMT2AKDM4EALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1019380-A2 | TRICYCLIC 3-OXO-PROPANENITRILE COMPOUNDS | PHARMACIA & UPJOHN S.p.A. (IT) | 2000-07-19 | — | — | EP | claimed |
| WO-1999016753-A2 | TRICYCLIC 3-OXO-PROPANENITRILE COMPOUNDS | PHARMACIA & UPJOHN S.P.A. (IT) | 1999-04-08 | — | — | WO | claimed |