Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTNNB1 | P35222 | 1/20 | 0.34 |
| ▸ | FDPS | P14324 | 1/20 | 0.34 |
| ▸ | ELANE | P08246 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 3/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8153984 | 0.91 | SMN1; SMN2 (0.35) | ELANEALDH1A1KDM4EMAPTHPGD | |
| SCHEMBL8155111 | 0.90 | ELANE (0.41) | CTNNB1ELANEKMT2A | |
| SCHEMBL8144738 | 0.90 | NPC1 (0.38) | ELANEALDH1A1KDM4EMAPTPOLB | |
| SCHEMBL8149948 | 0.89 | HPGD (0.34) | ELANEALDH1A1KDM4EMAPTHPGD | |
| SCHEMBL8152931 | 0.86 | CNR2 (0.44) | ELANEKDM4EMAPTHPGDSMN1; SMN2 | |
| SCHEMBL8152068 | 0.85 | ALOX5 (0.41) | ELANEALDH1A1MAPTHPGDPOLB | |
| SCHEMBL8158627 | 0.85 | MEN1 (0.32) | ALDH1A1KDM4EMAPTHPGDSMN1; SMN2 | |
| SCHEMBL8143616 | 0.84 | ALDH1A1 (0.44) | ALDH1A1KDM4EMAPTHPGDPOLB | |
| SCHEMBL8143240 | 0.84 | HTR3A (0.36) | ALDH1A1KDM4EMAPTHPGDPOLB | |
| SCHEMBL8060309 | 0.82 | KDM4E (0.50) | ELANEALDH1A1KDM4EMAPK1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1019380-A2 | TRICYCLIC 3-OXO-PROPANENITRILE COMPOUNDS | PHARMACIA & UPJOHN S.p.A. (IT) | 2000-07-19 | — | — | EP | claimed |
| WO-1999016753-A2 | TRICYCLIC 3-OXO-PROPANENITRILE COMPOUNDS | PHARMACIA & UPJOHN S.P.A. (IT) | 1999-04-08 | — | — | WO | claimed |
| EP-1019380-A2 | TRICYCLIC 3-OXO-PROPANENITRILE COMPOUNDS | PHARMACIA & UPJOHN S.p.A. (IT) | 2000-07-19 | — | — | EP | disclosed |
| WO-1999016753-A2 | TRICYCLIC 3-OXO-PROPANENITRILE COMPOUNDS | PHARMACIA & UPJOHN S.P.A. (IT) | 1999-04-08 | — | — | WO | disclosed |