Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.34 |
| ▸ | HPGD | P15428 | 4/20 | 0.34 |
| ▸ | LMNA | P02545 | 3/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | ALPG | P10696 | 2/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 4/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | ELANE | P08246 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8152609 | 0.91 | CTNNB1 (0.34) | SMN1; SMN2ALDH1A1HPGDHTTMAPT | |
| SCHEMBL8149948 | 0.90 | HPGD (0.34) | SMN1; SMN2ALDH1A1HPGDLMNANPSR1 | |
| SCHEMBL8144738 | 0.88 | NPC1 (0.38) | ALDH1A1LMNAALPGUSP2MAPT | |
| SCHEMBL8151959 | 0.87 | MAPT (0.38) | SMN1; SMN2ALDH1A1LMNAMAPTKDM4E | |
| SCHEMBL8155111 | 0.84 | ELANE (0.41) | ELANEL3MBTL1KCNJ11MEN1KMT2A | |
| SCHEMBL8152931 | 0.82 | CNR2 (0.44) | SMN1; SMN2HPGDLMNANPSR1HTT | |
| SCHEMBL8134922 | 0.81 | METAP2 (0.35) | SMN1; SMN2HTTKDM4EPKM | |
| SCHEMBL8143616 | 0.80 | ALDH1A1 (0.44) | SMN1; SMN2ALDH1A1HPGDLMNAUSP2 | |
| SCHEMBL8131769 | 0.80 | SRC (0.37) | SMN1; SMN2ALDH1A1HPGDLMNAHTT | |
| SCHEMBL8152068 | 0.80 | ALOX5 (0.41) | SMN1; SMN2ALDH1A1HPGDLMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1019380-A2 | TRICYCLIC 3-OXO-PROPANENITRILE COMPOUNDS | PHARMACIA & UPJOHN S.p.A. (IT) | 2000-07-19 | — | — | EP | disclosed |
| WO-1999016753-A2 | TRICYCLIC 3-OXO-PROPANENITRILE COMPOUNDS | PHARMACIA & UPJOHN S.P.A. (IT) | 1999-04-08 | — | — | WO | disclosed |