Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3A | P46098 | 2/20 | 0.42 |
| ▸ | CDK9 | P50750 | 1/20 | 0.42 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA7 | P43166 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 3/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7354285 | 0.84 | HTR3A (0.55) | HTR3ACDK9DYRK1AKMT2AMEN1 | |
| SCHEMBL8157833 | 0.83 | HTR3A (0.38) | HTR3AKMT2AMEN1ALDH1A1KDM4E | |
| SCHEMBL8160781 | 0.82 | MEN1 (0.44) | CDK9DYRK1AKMT2AMEN1PKM | |
| SCHEMBL8143240 | 0.80 | HTR3A (0.36) | HTR3ACDK9DYRK1AKMT2AMEN1 | |
| SCHEMBL8149911 | 0.78 | HTR3A (0.35) | HTR3ACDK9DYRK1AKMT2AMEN1 | |
| SCHEMBL8159020 | 0.78 | HDAC3 (0.38) | HTR3AKMT2AMEN1ALDH1A1KDM4E | |
| SCHEMBL8159022 | 0.78 | HDAC3 (0.38) | HTR3AKMT2AMEN1ALDH1A1KDM4E | |
| SCHEMBL8154303 | 0.76 | FDPS (0.47) | KMT2AMEN1PKMALDH1A1KDM4E | |
| SCHEMBL21816286 | 0.75 | MAPT (0.55) | HTR3ACDK9DYRK1AKMT2AMEN1 | |
| SCHEMBL9024540 | 0.72 | KMT2A (0.45) | CDK9DYRK1AKMT2AMEN1PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1019380-A2 | TRICYCLIC 3-OXO-PROPANENITRILE COMPOUNDS | PHARMACIA & UPJOHN S.p.A. (IT) | 2000-07-19 | — | — | EP | disclosed |
| WO-1999016753-A2 | TRICYCLIC 3-OXO-PROPANENITRILE COMPOUNDS | PHARMACIA & UPJOHN S.P.A. (IT) | 1999-04-08 | — | — | WO | disclosed |