Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FDPS | P14324 | 2/20 | 0.47 |
| ▸ | WDR5 | P61964 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | LDHA | P00338 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.40 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.40 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.40 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.40 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.40 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | STAT1 | P42224 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8156586 | 0.86 | FDPS (0.39) | FDPSKDM4EHPGDL3MBTL1ALDH1A1 | |
| SCHEMBL8135748 | 0.81 | MAPK1 (0.47) | FDPSWDR5KDM4EHPGDLDHA | |
| SCHEMBL8157443 | 0.81 | KDM4E (0.39) | KDM4EHPGDALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL8156861 | 0.79 | ALDH1A1 (0.41) | FDPSKDM4EHPGDALDH1A1POLB | |
| SCHEMBL8160781 | 0.79 | MEN1 (0.44) | KDM4EALDH1A1PKMSTAT1MEN1 | |
| SCHEMBL7360572 | 0.78 | HTR3A (0.52) | KDM4EHPGDL3MBTL1ALDH1A1POLB | |
| SCHEMBL8152609 | 0.77 | CTNNB1 (0.34) | FDPSKDM4EHPGDALDH1A1POLB | |
| SCHEMBL8158820 | 0.76 | HTR3A (0.42) | KDM4EHPGDALDH1A1PKMMAPT | |
| SCHEMBL31647374 | 0.76 | SSTR4 (0.46) | PKMAKR1B1MAPTSTAT1MEN1 | |
| SCHEMBL8144943 | 0.76 | TP53 (0.42) | KDM4EHPGDALDH1A1POLBPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1019380-A2 | TRICYCLIC 3-OXO-PROPANENITRILE COMPOUNDS | PHARMACIA & UPJOHN S.p.A. (IT) | 2000-07-19 | — | — | EP | disclosed |
| WO-1999016753-A2 | TRICYCLIC 3-OXO-PROPANENITRILE COMPOUNDS | PHARMACIA & UPJOHN S.P.A. (IT) | 1999-04-08 | — | — | WO | disclosed |