Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | ACP1 | P24666 | 1/20 | 0.35 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.34 |
| ▸ | CDK2 | P24941 | 1/20 | 0.34 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 2/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8151418 | 0.88 | TP53 (0.42) | TP53LMNAACP1ADORA3SMN1; SMN2 | |
| SCHEMBL8060667 | 0.82 | KDM4E (0.49) | CYP1A2CYP2C19TSHRKDM4EALDH1A1 | |
| Water SCHEMBL8066910 | 0.82 | KDM4E (0.49) | CYP1A2CYP2C19TSHRKDM4EALDH1A1 | |
| SCHEMBL8153723 | 0.79 | TP53 (0.43) | TP53LMNAADORA3SMN1; SMN2RIPK1 | |
| SCHEMBL8131769 | 0.78 | SRC (0.37) | LMNASMN1; SMN2RIPK1CYP1A2CYP2C19 | |
| SCHEMBL8151959 | 0.77 | MAPT (0.38) | TP53LMNASMN1; SMN2RIPK1MAPT | |
| SCHEMBL8060255 | 0.76 | MAPT (0.36) | LMNASMN1; SMN2CYP1A2CYP2C19TSHR | |
| SCHEMBL8061148 | 0.76 | SRC (0.43) | SMN1; SMN2MAPTKDM4EELANE | |
| SCHEMBL8144943 | 0.75 | TP53 (0.42) | TP53LMNASMN1; SMN2RIPK1TSHR | |
| SCHEMBL8060382 | 0.75 | KDM4E (0.46) | TP53SMN1; SMN2TSHRMAPTPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1019380-A2 | TRICYCLIC 3-OXO-PROPANENITRILE COMPOUNDS | PHARMACIA & UPJOHN S.p.A. (IT) | 2000-07-19 | — | — | EP | disclosed |
| WO-1999016753-A2 | TRICYCLIC 3-OXO-PROPANENITRILE COMPOUNDS | PHARMACIA & UPJOHN S.P.A. (IT) | 1999-04-08 | — | — | WO | disclosed |