Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDB1 | Q16531 | 1/20 | 0.39 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.38 |
| ▸ | RELA | Q04206 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.38 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | RAD52 | P43351 | 1/20 | 0.38 |
| ▸ | GFER | P55789 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | CTSD | P07339 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18576158 | 0.73 | TSHR (0.42) | DDB1CRBNNFKB1NFKB2RELA | |
| SCHEMBL4522442 | 0.73 | JAK3 (0.36) | DDB1CRBNNFKB1NFKB2RELA | |
| SCHEMBL17674128 | 0.70 | SLC6A2 (0.46) | DDB1CRBNNFKB1NFKB2RELA | |
| SCHEMBL5309238 | 0.70 | DDB1 (0.42) | DDB1CRBNALDH1A1MAPK1CYP1A2 | |
| SCHEMBL8304925 | 0.69 | ADRA2A (0.51) | ALDH1A1IDO1CYP3A4 | |
| SCHEMBL21409364 | 0.69 | MAP2K1 (0.37) | DDB1CRBNNFKB1NFKB2RELA | |
| SCHEMBL2229850 | 0.69 | POLB (0.44) | DDB1CRBNALDH1A1SLC6A2 | |
| SCHEMBL8551724 | 0.68 | — | — | |
| SCHEMBL918020 | 0.68 | HTR6 (0.49) | ALDH1A1ALOX15ALOX12L3MBTL1LMNA | |
| SCHEMBL9116182 | 0.67 | DDB1 (0.37) | DDB1CRBNNFKB1NFKB2RELA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2486009-B1 | 2H-PYRROL-5-AMINE DERIVATIVES AS ALPHA ADRENERGIC RECEPTOR MODULATORS | ALLERGAN INC (US) | 2019-08-21 | — | — | EP | disclosed |
| CN-1617857-A | 2'-halo-3',5'-dialkoxyphen-1'-yl-imino-2-imidazolidine derivative and the use thereof as a drug for curing urinary incontinence | BOEHRINGER INGELHEIM PHARMA (DE) | 2005-05-18 | — | — | CN | disclosed |
| EP-0735877-B1 | 6-(2-IMIDAZOLINYLAMINO)QUINOXALINE COMPOUNDS USEFUL AS ALPHA-2 ADRENOCEPTOR AGONISTS | PROCTER & GAMBLE (US) | 2000-07-19 | — | — | EP | disclosed |
| EP-0083729-B1 | SUBSTITUTED 1-BENZOYL-2-PHENYLIMINO-IMIDAZOLIDINES, THEIR ACID ADDITION SALTS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | CHEMIE LINZ AKTIENGESELLSCHAFT (AT) | 1986-02-26 | — | — | EP | disclosed |
| EP-0083729-A1 | Substituted 1-benzoyl-2-phenylimino-imidazolidines, their acid addition salts, process for their preparation and pharmaceutical compositions containing them | CHEMIE LINZ AKTIENGESELLSCHAFT (AT) | 1983-07-20 | — | — | EP | disclosed |
| US-4250186-A | ADMINISTERING A 2-(SUBSTITUTED PHENYL-IMINO)-IMIDAZOLIDINE COMPOUND | BOEHRINGER INGELHEIM GMBH (DE) | 1981-02-10 | — | — | US | disclosed |