Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 2/20 | 0.51 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.47 |
| ▸ | FADS1 | O60427 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
| ▸ | MAPK10 | P53779 | 8/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | ALPL | P05186 | 1/20 | 0.42 |
| ▸ | IDO1 | P14902 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | TTK | P33981 | 1/20 | 0.42 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.41 |
| ▸ | MAPK8 | P45983 | 5/20 | 0.40 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.40 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.40 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.40 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15392392 | 0.76 | TRPA1 (0.54) | ADRA2ATRPA1FADS1KDM4EGAA | |
| SCHEMBL19100299 | 0.72 | MAPK1 (0.49) | ADRA2ATRPA1ACHEMAPK10MCHR1 | |
| SCHEMBL11700794 | 0.72 | KDM4E (0.57) | ADRA2ATRPA1FADS1KDM4EGAA | |
| SCHEMBL11756891 | 0.72 | TRPA1 (0.54) | ADRA2ATRPA1FADS1KDM4EGAA | |
| SCHEMBL7172053 | 0.72 | TRPA1 (0.54) | ADRA2ATRPA1FADS1KDM4EGAA | |
| SCHEMBL7452500 | 0.72 | TRPA1 (0.54) | ADRA2ATRPA1FADS1KDM4EGAA | |
| SCHEMBL31032755 | 0.72 | TRPA1 (0.54) | ADRA2ATRPA1FADS1KDM4EGAA | |
| SCHEMBL2854739 | 0.71 | TRPA1 (0.50) | ADRA2ATRPA1FADS1KDM4EGAA | |
| SCHEMBL966349 | 0.71 | TRPA1 (0.50) | ADRA2ATRPA1FADS1KDM4EGAA | |
| SCHEMBL20812420 | 0.69 | DDB1 (0.59) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0944620-A1 | 2-IMIDAZOLINYLAMINOINDAZOLE COMPOUNDS USEFUL AS ALPHA-2 ADRENOCEPTOR AGONISTS | THE PROCTER & GAMBLE COMPANY (US) | 1999-09-29 | — | — | EP | disclosed |
| WO-1998023609-A1 | 2-IMIDAZOLINYLAMINOINDAZOLE COMPOUNDS USEFUL AS ALPHA-2 ADRENOCEPTOR AGONISTS | THE PROCTER & GAMBLE COMPANY (US) | 1998-06-04 | — | — | WO | disclosed |