Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CREBBP | Q92793 | 2/20 | 0.42 |
| ▸ | RXRA | P19793 | 2/20 | 0.42 |
| ▸ | PPARG | P37231 | 2/20 | 0.42 |
| ▸ | RARG | P13631 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | ESRRA | P11474 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.37 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | BRD2 | P25440 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | CA5A | P35218 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1190498 | 0.90 | TSHR (0.53) | CREBBPTSHRCYP3A4LMNASMN1; SMN2 | |
| SCHEMBL1188354 | 0.90 | ESRRA (0.42) | CREBBPRXRAPPARGRARGTSHR | |
| SCHEMBL16502258 | 0.90 | RXRA (0.39) | CREBBPRXRAPPARGRARGTSHR | |
| SCHEMBL10204587 | 0.88 | BPTF (0.49) | CREBBPTSHRCYP3A4LMNASMN1; SMN2 | |
| SCHEMBL8008640 | 0.86 | RXRA (0.44) | RXRAPPARGRARGLMNARECQL | |
| SCHEMBL7792646 | 0.86 | TSHR (0.42) | RXRAPPARGRARGTSHRLMNA | |
| SCHEMBL14204866 | 0.86 | ESRRA (0.40) | LMNARECQLESRRASMN1; SMN2HSP90AA1 | |
| SCHEMBL10204490 | 0.85 | RXRA (0.39) | CREBBPRXRAPPARGRARGTSHR | |
| SCHEMBL8000062 | 0.85 | RXRA (0.46) | RXRAPPARGRARGLMNAESRRA | |
| SCHEMBL8000079 | 0.83 | THRA (0.47) | RXRAPPARGTHRBGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6083977-A | HAVING ACTIVITY FOR RETINOIC ACID RECEPTORS AND RETINOID X RECEPTORS | LIGAND PHARMACEUTICALS INCORPORATED (US) | 2000-07-04 | — | — | US | disclosed |
| EP-0800503-B1 | NOVEL TRIENOIC RETINOID COMPOUNDS AND METHODS | LIGAND PHARM INC (US) | 2000-05-10 | — | — | EP | disclosed |
| US-5721103-A | SKIN DISORDERS; VISION DEFECTS | LIGAND PHARMACEUTICALS INCORPORATED (US) | 1998-02-24 | — | — | US | disclosed |
| EP-0800503-A1 | NOVEL TRIENOIC RETINOID COMPOUNDS AND METHODS | LIGAND PHARMACEUTICALS, INC. (US) | 1997-10-15 | — | — | EP | disclosed |
| WO-1996020913-A1 | NOVEL TRIENOIC RETINOID COMPOUNDS AND METHODS | LIGAND PHARMACEUTICALS INCORPORATED (US) | 1996-07-11 | — | — | WO | disclosed |