Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 6/20 | 0.44 |
| ▸ | PPARG | P37231 | 4/20 | 0.44 |
| ▸ | RARG | P13631 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | ESRRA | P11474 | 1/20 | 0.38 |
| ▸ | THRA | P10827 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8000062 | 0.92 | RXRA (0.46) | RXRAPPARGRARGLMNAESRRA | |
| SCHEMBL8000079 | 0.90 | THRA (0.47) | RXRAPPARGTHRATHRBL3MBTL1 | |
| SCHEMBL8010874 | 0.89 | THRA (0.49) | RXRATHRATHRB | |
| SCHEMBL8014571 | 0.89 | THRA (0.49) | RXRATHRATHRB | |
| SCHEMBL8439090 | 0.89 | THRA (0.49) | RXRATHRATHRB | |
| SCHEMBL8159583 | 0.86 | CREBBP (0.42) | RXRAPPARGRARGSMN1; SMN2KMT2A | |
| SCHEMBL14204866 | 0.83 | ESRRA (0.40) | SMN1; SMN2LMNARECQLESRRAL3MBTL1 | |
| SCHEMBL4731276 | 0.80 | ESRRA (0.38) | RARGLMNARECQLESRRAPTGS1 | |
| SCHEMBL7331449 | 0.78 | VCAM1 (0.41) | KMT2AMEN1LMNAESRRA | |
| SCHEMBL1190498 | 0.78 | TSHR (0.53) | SMN1; SMN2KMT2AALDH1A1MEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2000026172-A1 | TRIENOIC RETINOID COMPOUNDS AS RETINOIC ACID RECEPTOR ANTAGONISTS | LIGAND PHARMACEUTICALS INCORPORATED (US) | 2000-05-11 | — | — | WO | disclosed |
| US-5998654-A | SKIN DISORDERS; ANTICANCER AGENTS | LIGAND PHARMACEUTICALS INCORPORATED (US) | 1999-12-07 | — | — | US | disclosed |