SCHEMBL8159873

SCHEMBL8159873

NC(CCc1ccccc1)C(NC(=O)[C@@H](N)Cc1ccc(C(=O)N2CCOCC2)cc1)S(=O)(=O)c1ccccc1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CTSB P07858 5/20 0.48
CTSL P07711 5/20 0.48
CTSK P43235 3/20 0.44
CTSS P25774 3/20 0.44
CTSH P09668 1/20 0.44
CTSC P53634 1/20 0.44
ACACB O00763 1/20 0.43
MASP2 O00187 1/20 0.43
F2 P00734 1/20 0.43
HPGD P15428 3/20 0.43
GAA P10253 1/20 0.42
HSD11B1 P28845 1/20 0.42
ALDH1A1 P00352 5/20 0.41
TSHR P16473 1/20 0.41
SMN1; SMN2 Q16637 2/20 0.41
HTT P42858 2/20 0.41
MEN1 O00255 1/20 0.41
KMT2A Q03164 1/20 0.41
NPC1 O15118 1/20 0.41
MAPT P10636 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7414219 0.90 CTSB (0.49) CTSBCTSLCTSKCTSSCTSH
SCHEMBL7595864 0.90 CTSB (0.49) CTSBCTSLCTSKCTSSCTSH
SCHEMBL8159870 0.83 CTSL (0.66) CTSBCTSLCTSKCTSSCTSH
SCHEMBL7411045 0.80 ACACB (0.46) CTSBCTSLCTSSACACBMASP2
SCHEMBL7354030 0.78 CTSL (0.59) CTSBCTSLCTSKCTSSCTSH
SCHEMBL7410501 0.78 ACACB (0.46) CTSBCTSLACACBHPGDGAA
SCHEMBL8516640 0.78 CTSL (0.64) CTSBCTSLCTSKCTSSCTSH
SCHEMBL7379877 0.77 ACACB (0.42) CTSBCTSLCTSSACACBMASP2
SCHEMBL7400381 0.74 CTSL (0.50) CTSBCTSLCTSKCTSSCTSH
SCHEMBL8156094 0.73 CTSL (0.55) CTSBCTSLCTSKCTSSCTSH

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6030946-A FUNCTIONS REVERSIBLY, RESULTING IN TIGHT BINDING (LOW DISSOCIATION CONSTANTS) BETWEEN INHIBITOR AND TARGET ENZYME; USED TO TREAT VARIETY OF DISEAES, INCLUDING ARTHRITIS, MUSCULAR DYSTROPHY, INFLAMMATION, TUMOR INVASION, MALERIA AXYS PHARMACEUTICALS, INC. (US) 2000-02-29 US disclosed
EP-0832099-A1 REVERSIBLE CYSTEINE PROTEASE INHIBITORS ARRIS PHARMACEUTICAL CORPORATION (US) 1998-04-01 EP disclosed
WO-1996040737-A1 REVERSIBLE CYSTEINE PROTEASE INHIBITORS ARRIS PHARMACEUTICAL CORPORATION (US) 1996-12-19 WO disclosed