SCHEMBL8159902

SCHEMBL8159902

IOCCCN1CCCC1

nearest known ligand 0.55

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
HRH3 Q9Y5N1 14/20 0.52
ALDH1A1 P00352 2/20 0.44
KCNH2 Q12809 1/20 0.43
CYP2D6 P10635 1/20 0.43
CYP2C19 P33261 1/20 0.43
ACHE P22303 1/20 0.43
RAD52 P43351 1/20 0.43
HRH1 P35367 1/20 0.42
KDM4E B2RXH2 1/20 0.42
SMN1; SMN2 Q16637 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14041546 0.98 HRH3 (0.56) HRH3KCNH2ACHERAD52HRH1
SCHEMBL22310345 0.93 HRH3 (0.56) HRH3ALDH1A1CYP2D6CYP2C19
Methylamine SCHEMBL1582949 0.91 HRH3 (0.50) HRH3ALDH1A1KCNH2CYP2D6CYP2C19
SCHEMBL14553250 0.91 HRH3 (0.61) HRH3KCNH2
SCHEMBL8229217 0.82 HRH3 (0.48) HRH3ALDH1A1
SCHEMBL23158211 0.82 KEAP1 (0.47) HRH3ALDH1A1KCNH2CYP2D6HRH1
SCHEMBL14041545 0.81 HRH3 (0.45) HRH3ALDH1A1KDM4E
SCHEMBL17982316 0.79 KEAP1 (0.54) HRH3ALDH1A1KCNH2CYP2D6HRH1
SCHEMBL7436131 0.79 HRH3 (0.58) HRH3ALDH1A1KCNH2CYP2D6CYP2C19
SCHEMBL21851011 0.78 HRH3 (0.46) HRH3HRH1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3848363-B1 TRICYCLIC SUBSTITUTED PIPERIDINE DIONE COMPOUND MEDSHINE DISCOVERY INC (CN) 2023-07-19 EP disclosed
US-20230151136-A1 CATALYST COMPOSITION FOR POLYURETHANES MOMENTIVE PERFORMANCE MATERIALS INC. 2023-05-18 US disclosed
EP-3848363-A1 TRICYCLIC SUBSTITUTED PIPERIDINE DIONE COMPOUND Medshine Discovery Inc. (CN) 2021-07-14 EP disclosed
WO-2021057832-A1 KRAS MUTANT PROTEIN INHIBITOR JACOBIO PHARMACEUTICALS CO., LTD. (CN) 2021-04-01 WO disclosed
WO-2019036384-A1 TRICYCLIC COMPOUNDS AS HISTONE METHYLTRANSFERASE INHIBITORS GLOBAL BLOOD THERAPEUTICS, INC. (US) 2019-02-21 WO disclosed
WO-2008086226-A2 FACTOR XA INHIBITORS MILLENNIUM PHARMACEUTICALS, INC. (US) 2008-07-17 WO disclosed