Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 9/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14553250 | 0.98 | HRH3 (0.61) | HRH3L3MBTL1ATM | |
| SCHEMBL8159902 | 0.93 | HRH3 (0.52) | HRH3ALDH1A1CYP2D6CYP2C19 | |
| SCHEMBL14041546 | 0.91 | HRH3 (0.56) | HRH3CYP1A2 | |
| Methylamine SCHEMBL1582949 | 0.85 | HRH3 (0.50) | HRH3L3MBTL1ALDH1A1CYP2D6CYP2C19 | |
| SCHEMBL23868249 | 0.80 | SMN1; SMN2 (0.52) | HRH3LMNAHTTALDH1A1CYP1A2 | |
| SCHEMBL20331332 | 0.80 | ALDH1A1 (0.49) | HRH3MEN1KMT2AALDH1A1 | |
| SCHEMBL21037024 | 0.80 | HRH3 (0.62) | HRH3L3MBTL1ATMMEN1LMNA | |
| SCHEMBL8229217 | 0.80 | HRH3 (0.48) | HRH3L3MBTL1MAPTALDH1A1 | |
| SCHEMBL5709253 | 0.79 | HRH3 (0.87) | HRH3MAPTCYP1A2 | |
| SCHEMBL23870328 | 0.77 | KDM4E (0.54) | HRH3MEN1LMNAKMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3919492-A1 | PYRIMIDINYL GROUP-CONTAINING TRICYCLIC COMPOUND SERVING AS C-MET INHIBITOR | Medshine Discovery Inc. (CN) | 2021-12-08 | — | — | EP | disclosed |
| WO-2020156453-A1 | PYRIMIDINYL GROUP-CONTAINING TRICYCLIC COMPOUND SERVING AS C-MET INHIBITOR | 南京明德新药研发有限公司 | 2020-08-06 | — | — | WO | disclosed |