Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
| ▸ | BLM | P54132 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | POLA1 | P09884 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10157871 | 0.80 | MKNK1 (0.45) | POLB | |
| SCHEMBL10156550 | 0.74 | POLB (0.48) | POLBMAPTBLMTDP1RECQL | |
| SCHEMBL10156777 | 0.73 | POLB (0.42) | POLBSMN1; SMN2MEN1KMT2A | |
| SCHEMBL10156704 | 0.73 | ROCK1 (0.45) | POLBMAPTUSP2SMN1; SMN2TSHR | |
| SCHEMBL10157157 | 0.72 | ROCK1 (0.50) | POLBMAPTBLMTDP1SMN1; SMN2 | |
| SCHEMBL17422233 | 0.70 | POLB (0.50) | POLBMAPTRAB9ASMN1; SMN2TSHR | |
| SCHEMBL10157834 | 0.70 | POLB (0.44) | POLBMAPTTHRBBLMHSD17B10 | |
| SCHEMBL10156964 | 0.70 | TNNI3K (0.55) | POLB | |
| SCHEMBL7962176 | 0.70 | UNG (0.57) | POLBMAPTHSD17B10POLA1SMN1; SMN2 | |
| SCHEMBL10157033 | 0.69 | POLB (0.48) | POLBUSP2SMN1; SMN2TSHRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0772439-B1 | Novel antibiotic compounds and antibiotic compositions comprising said compounds for inhibiting gram positive bacteria and mycoplasma cells. | UNIV MASSACHUSETTS MEDICAL (US) | 2000-10-04 | — | — | EP | disclosed |
| EP-0772439-A4 | NOVEL ANTIBIOTIC COMPOUNDS AND METHODS TO TREAT GRAM-POSITIVE BACTERIAL AND MYCOPLASMAL INFECTIONS | UNIV MASSACHUSETTS MEDICAL (US) | 1998-01-07 | — | — | EP | disclosed |
| EP-0772439-A1 | NOVEL ANTIBIOTIC COMPOUNDS AND METHODS TO TREAT GRAM-POSITIVE BACTERIAL AND MYCOPLASMAL INFECTIONS | UNIVERSITY OF MASSACHUSETTS MEDICAL CENTER (US) | 1997-05-14 | — | — | EP | disclosed |
| US-5516905-A | ENZYME INHIBITORS OF DNA POLYMERASE FOR BACTERICIDES | UNIVERSITY OF MASSACHUSETTS MEDICAL CENTER (US) | 1996-05-14 | — | — | US | disclosed |
| WO-1996006614-A1 | NOVEL ANTIBIOTIC COMPOUNDS AND METHODS TO TREAT GRAM-POSITIVE BACTERIAL AND MYCOPLASMAL INFECTIONS | UNIVERSITY OF MASSACHUSETTS MEDICAL CENTER (US) | 1996-03-07 | — | — | WO | disclosed |