Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.46 |
| ▸ | GRM5 | P41594 | 7/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | CETP | P11597 | 1/20 | 0.38 |
| ▸ | APP | P05067 | 1/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.37 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.37 |
| ▸ | HTR3B | O95264 | 1/20 | 0.37 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.37 |
| ▸ | HTR3A | P46098 | 1/20 | 0.37 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.37 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.37 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14666451 | 0.85 | SIGMAR1 (0.61) | SIGMAR1POLBUSP2ALDH1A1TSHR | |
| SCHEMBL3640363 | 0.81 | SIGMAR1 (0.73) | SIGMAR1GRM5 | |
| SCHEMBL8162119 | 0.81 | GRM5 (0.68) | GRM5POLBALDH1A1TSHR | |
| SCHEMBL8163323 | 0.80 | GRM5 (0.69) | GRM5APP | |
| SCHEMBL8163764 | 0.80 | GRM5 (0.48) | GRM5POLBUSP2ALDH1A1TSHR | |
| SCHEMBL8161856 | 0.80 | GRM5 (0.50) | GRM5 | |
| SCHEMBL16383677 | 0.78 | LTA4H (0.47) | SIGMAR1POLBUSP2ALDH1A1TSHR | |
| SCHEMBL8154259 | 0.78 | GRM3 (0.52) | GRM5POLBALDH1A1 | |
| SCHEMBL8171420 | 0.78 | GRM5 (0.49) | GRM5 | |
| SCHEMBL8166622 | 0.77 | CA12 (0.45) | SIGMAR1GRM5POLBALDH1A1OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008151184-A1 | BENZAMIDE MGLUR5 POSITIVE ALLOSTERIC MODULATORS AND METHODS OF MAKING AND USING SAME | VANDERBILT UNIVERSITY (US) | 2008-12-11 | — | — | WO | disclosed |