Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 4/20 | 0.39 |
| ▸ | RAB9A | P51151 | 4/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | NAMPT | P43490 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.35 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.35 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.35 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.35 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4220849 | 0.82 | GRM5 (0.65) | GRM5L3MBTL1SMN1; SMN2HPGDNAMPT | |
| SCHEMBL3638834 | 0.82 | GRM5 (0.65) | GRM5L3MBTL1SMN1; SMN2HPGDNAMPT | |
| SCHEMBL8163323 | 0.79 | GRM5 (0.69) | GRM5MAPTLMNAGAAL3MBTL1 | |
| SCHEMBL8160767 | 0.69 | GRM5 (0.52) | GRM5 | |
| SCHEMBL8159268 | 0.69 | GRM5 (0.52) | GRM5L3MBTL1NPC1RAB9AMEN1 | |
| SCHEMBL13931022 | 0.69 | ACHE (0.74) | GRM5LMNAGAANPC1RAB9A | |
| SCHEMBL1934947 | 0.67 | HPGD (0.55) | GAANPC1HPGDHTTMEN1 | |
| SCHEMBL24722046 | 0.67 | L3MBTL3 (0.67) | L3MBTL1 | |
| SCHEMBL26606126 | 0.67 | ACHE (0.42) | MAPTLMNAL3MBTL1NPC1SMN1; SMN2 | |
| SCHEMBL21976176 | 0.67 | CA12 (0.49) | NPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008151184-A1 | BENZAMIDE MGLUR5 POSITIVE ALLOSTERIC MODULATORS AND METHODS OF MAKING AND USING SAME | VANDERBILT UNIVERSITY (US) | 2008-12-11 | — | — | WO | disclosed |