Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPC3 | Q13507 | 1/20 | 0.45 |
| ▸ | TRPC7 | Q9HCX4 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | GRIN2B | Q13224 | 10/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.40 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8174942 | 0.89 | ADRA1D (0.45) | TRPC3TRPC7SMN1; SMN2NPC1RAB9A | |
| SCHEMBL8166072 | 0.87 | TRPC3 (0.45) | TRPC3TRPC7SMN1; SMN2NPC1RAB9A | |
| SCHEMBL8174460 | 0.81 | TRPC3 (0.52) | TRPC3TRPC7SMN1; SMN2NPC1RAB9A | |
| SCHEMBL2860117 | 0.79 | SMN1; SMN2 (0.53) | TRPC3TRPC7SMN1; SMN2NPC1RAB9A | |
| SCHEMBL27763184 | 0.73 | SMN1; SMN2 (0.50) | TRPC3TRPC7SMN1; SMN2NPC1RAB9A | |
| SCHEMBL1652086 | 0.72 | GRIN2B (0.52) | TRPC3TRPC7SMN1; SMN2NPC1RAB9A | |
| SCHEMBL3107460 | 0.71 | GRIN2B (0.50) | TRPC3TRPC7SMN1; SMN2NPC1RAB9A | |
| SCHEMBL8175103 | 0.71 | TRPC3 (0.49) | TRPC3TRPC7SMN1; SMN2NPC1RAB9A | |
| SCHEMBL28776231 | 0.71 | GRIN2B (0.47) | TRPC3TRPC7SMN1; SMN2NPC1RAB9A | |
| SCHEMBL8174185 | 0.70 | LMNA (0.45) | SMN1; SMN2HTTMEN1KMT2ANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6090825-A | Oxazole derivatives as antagonists of alpha 1C andrenergic receptors | GLAXO WELLCOME INC. (US) | 2000-07-18 | — | — | US | disclosed |
| EP-0793658-A1 | OXAZOLE DERIVATIVES AS ANTAGONISTS OF ALPHA-1C ADRENERGIC RECEPTORS | GLAXO WELLCOME INC. (US) | 1997-09-10 | — | — | EP | disclosed |
| WO-1996016049-A1 | OXAZOLE DERIVATIVES AS ANTAGONISTS OF α-1C ADRENERGIC RECEPTORS | GLAXO WELLCOME INC. (US) | 1996-05-30 | — | — | WO | disclosed |