Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPC3 | Q13507 | 2/20 | 0.49 |
| ▸ | TRPC7 | Q9HCX4 | 2/20 | 0.49 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.46 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | GRIN2B | Q13224 | 5/20 | 0.41 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.41 |
| ▸ | FAAH | O00519 | 2/20 | 0.40 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8174460 | 0.87 | TRPC3 (0.52) | TRPC3TRPC7SMN1; SMN2NPC1RAB9A | |
| SCHEMBL8174942 | 0.84 | ADRA1D (0.45) | TRPC3TRPC7ADRA1DADRA1AADRA1B | |
| SCHEMBL8166223 | 0.82 | ADRA1D (0.47) | ADRA1DADRA1AADRA1BSMN1; SMN2FAAH | |
| SCHEMBL27763184 | 0.81 | SMN1; SMN2 (0.50) | TRPC3TRPC7SMN1; SMN2NPC1RAB9A | |
| SCHEMBL8178641 | 0.81 | ADRA1D (0.49) | ADRA1DADRA1AADRA1BCYP2C9 | |
| SCHEMBL3100028 | 0.79 | CETP (0.47) | TRPC3TRPC7SMN1; SMN2NPC1RAB9A | |
| SCHEMBL3097583 | 0.79 | TRPC3 (0.50) | TRPC3TRPC7SMN1; SMN2NPC1RAB9A | |
| SCHEMBL2712215 | 0.79 | TNKS (0.53) | TRPC3TRPC7SMN1; SMN2NPC1RAB9A | |
| Trifluoroacetic Acid SCHEMBL8166220 | 0.78 | ADRA1D (0.42) | ADRA1DADRA1AADRA1BSMN1; SMN2CYP2C19 | |
| SCHEMBL8166794 | 0.78 | ADRA1D (0.57) | ADRA1DADRA1AADRA1BSMN1; SMN2FAAH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6090825-A | Oxazole derivatives as antagonists of alpha 1C andrenergic receptors | GLAXO WELLCOME INC. (US) | 2000-07-18 | — | — | US | disclosed |
| EP-0793658-A1 | OXAZOLE DERIVATIVES AS ANTAGONISTS OF ALPHA-1C ADRENERGIC RECEPTORS | GLAXO WELLCOME INC. (US) | 1997-09-10 | — | — | EP | disclosed |
| WO-1996016049-A1 | OXAZOLE DERIVATIVES AS ANTAGONISTS OF α-1C ADRENERGIC RECEPTORS | GLAXO WELLCOME INC. (US) | 1996-05-30 | — | — | WO | disclosed |