Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAT1 | P18440 | 3/20 | 0.74 |
| ▸ | PIM1 | P11309 | 1/20 | 0.56 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.56 |
| ▸ | GSK3B | P49841 | 1/20 | 0.55 |
| ▸ | ADAMTS5 | Q9UNA0 | 2/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.50 |
| ▸ | CISD1 | Q9NZ45 | 2/20 | 0.50 |
| ▸ | PNP | P00491 | 1/20 | 0.50 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.46 |
| ▸ | CRHBP | P24387 | 1/20 | 0.46 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.46 |
| ▸ | MMP3 | P08254 | 1/20 | 0.46 |
| ▸ | MMP13 | P45452 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8166383 | 1.00 | NAT1 (0.74) | NAT1PIM1PIM2GSK3BADAMTS5 | |
| SCHEMBL7557614 | 0.85 | NAT1 (1.00) | NAT1PIM1PIM2GSK3BADAMTS5 | |
| SCHEMBL7557609 | 0.85 | NAT1 (1.00) | NAT1PIM1PIM2GSK3BADAMTS5 | |
| SCHEMBL8189394 | 0.81 | ADAMTS5 (0.78) | NAT1GSK3BADAMTS5TDP1MMP3 | |
| SCHEMBL8189396 | 0.81 | ADAMTS5 (0.78) | NAT1GSK3BADAMTS5TDP1MMP3 | |
| SCHEMBL29825140 | 0.78 | CISD1 (0.76) | NAT1PIM1PIM2ADAMTS5TDP1 | |
| SCHEMBL8172626 | 0.73 | MEN1 (0.73) | NAT1PIM1PIM2GSK3BTDP1 | |
| SCHEMBL8172622 | 0.73 | MEN1 (0.73) | NAT1PIM1PIM2GSK3BTDP1 | |
| SCHEMBL8189119 | 0.72 | ALDH1A1 (0.41) | NAT1GSK3BADAMTS5TDP1CISD1 | |
| SCHEMBL8189117 | 0.72 | ALDH1A1 (0.41) | NAT1GSK3BADAMTS5TDP1CISD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2000018748-A1 | RHODANINE DERIVATIVES FOR THE TREATMENT AND PREVENTION OF METABOLIC BONE DISORDERS | ROCHE DIAGNOSTICS GMBH (DE) | 2000-04-06 | — | — | WO | disclosed |