Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 4/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.38 |
| ▸ | RELA | Q04206 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | NFE2L2 | Q16236 | 6/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.33 |
| ▸ | MAT2A | P31153 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8166833 | 1.00 | PTGS2 (0.38) | PTGS2MEN1KMT2ANPC1NFKB1 | |
| SCHEMBL7930611 | 0.79 | PTGS2 (0.44) | PTGS2MEN1KMT2ANPC1NFKB1 | |
| SCHEMBL7922901 | 0.78 | NFE2L2 (0.41) | NPC1RAB9ASMN1; SMN2L3MBTL1NFE2L2 | |
| SCHEMBL7922895 | 0.78 | NFE2L2 (0.41) | NPC1RAB9ASMN1; SMN2L3MBTL1NFE2L2 | |
| SCHEMBL1047349 | 0.72 | MEN1 (0.45) | PTGS2MEN1KMT2ANPC1NFKB1 | |
| SCHEMBL7932764 | 0.72 | SYK (0.37) | RAB9ASMN1; SMN2L3MBTL1NFE2L2MAPT | |
| SCHEMBL7932759 | 0.72 | SYK (0.37) | RAB9ASMN1; SMN2L3MBTL1NFE2L2MAPT | |
| SCHEMBL30638498 | 0.72 | L3MBTL1 (0.56) | PTGS2MEN1KMT2ANPC1NFKB1 | |
| SCHEMBL265482 | 0.72 | L3MBTL1 (0.56) | PTGS2MEN1KMT2ANPC1NFKB1 | |
| SCHEMBL7931959 | 0.72 | NFE2L2 (0.38) | MEN1KMT2ANPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6150413-A | TREATMENT OF DERMATOLOGICAL, RHEUMATIC, RESPIRATORY, CARDIOVASCULAR, BONE AND OPHTHALMOLOGICAL DISORDERS, AS WELL AS MAMMALIAN SKIN AND HAIR CONDITIONS; 4-(4-(BIPHENYL-2-YL)BUT-3-EN-1-YNYL)BENZOIC ACID, FOR EXAMPLE | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES (FR) | 2000-11-21 | — | — | US | disclosed |