Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 4/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | ESR1 | P03372 | 1/20 | 0.41 |
| ▸ | THRA | P10827 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | VDR | P11473 | 1/20 | 0.41 |
| ▸ | RXRA | P19793 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7929254 | 0.91 | SLC16A3 (0.44) | RXRAPPARDVCPHDAC8HSP90AA1 | |
| SCHEMBL8175387 | 0.89 | MAPT (0.40) | RAB9ANPC1MAPTLMNAHTT | |
| SCHEMBL8180309 | 0.88 | HSD17B10 (0.40) | RAB9ANPC1MAPTSMN1; SMN2POLB | |
| SCHEMBL8167571 | 0.88 | EGFR (0.41) | ALDH1A1HPGDHSD17B10CA1CA2 | |
| SCHEMBL8175054 | 0.88 | MAPT (0.44) | RAB9ANPC1MAPTLMNAHTT | |
| SCHEMBL8167359 | 0.88 | CA1 (0.47) | RAB9ANPC1MAPTLMNASMN1; SMN2 | |
| SCHEMBL8175916 | 0.88 | EGFR (0.46) | RAB9ANPC1MAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL8180652 | 0.88 | MAPK14 (0.39) | NPC1MAPTSMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL8180152 | 0.83 | CA1 (0.46) | LMNAALDH1A1HPGDHSD17B10CA1 | |
| SCHEMBL8167327 | 0.83 | TDP1 (0.46) | RAB9ANPC1MAPTSMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6150413-A | TREATMENT OF DERMATOLOGICAL, RHEUMATIC, RESPIRATORY, CARDIOVASCULAR, BONE AND OPHTHALMOLOGICAL DISORDERS, AS WELL AS MAMMALIAN SKIN AND HAIR CONDITIONS; 4-(4-(BIPHENYL-2-YL)BUT-3-EN-1-YNYL)BENZOIC ACID, FOR EXAMPLE | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES (FR) | 2000-11-21 | — | — | US | disclosed |