SCHEMBL8175387

SCHEMBL8175387

COCOc1cccc(-c2ccccc2/C=C/C#Cc2ccc(C(=O)OC)cc2)c1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 5/20 0.40
RAB9A P51151 4/20 0.40
NPC1 O15118 3/20 0.37
SMN1; SMN2 Q16637 2/20 0.37
POLB P06746 2/20 0.37
BLM P54132 2/20 0.37
EGFR P00533 3/20 0.37
ESR1 P03372 1/20 0.36
THRA P10827 1/20 0.36
THRB P10828 1/20 0.36
VDR P11473 1/20 0.36
RXRA P19793 1/20 0.36
PPARG P37231 1/20 0.36
PPARD Q03181 1/20 0.36
PPARA Q07869 1/20 0.36
ESR2 Q92731 1/20 0.36
FYN P06241 2/20 0.36
NEK1 Q96PY6 1/20 0.36
KDM4E B2RXH2 1/20 0.35
FFAR1 O14842 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7930701 0.91 EGFR (0.43) EGFRRXRAFYNFFAR1PTGER1
SCHEMBL8176971 0.90 MAPT (0.43) MAPTRAB9ANPC1SMN1; SMN2POLB
SCHEMBL8175054 0.90 MAPT (0.44) MAPTRAB9ANPC1SMN1; SMN2POLB
SCHEMBL8167132 0.89 RAB9A (0.44) MAPTRAB9ANPC1SMN1; SMN2POLB
SCHEMBL8167571 0.84 EGFR (0.41) EGFRKDM4EPTGER1PTGER4PTGER3
SCHEMBL8180309 0.84 HSD17B10 (0.40) MAPTRAB9ANPC1SMN1; SMN2POLB
SCHEMBL8175916 0.84 EGFR (0.46) MAPTRAB9ANPC1SMN1; SMN2EGFR
SCHEMBL8180652 0.83 MAPK14 (0.39) MAPTNPC1SMN1; SMN2EGFRPTGER1
SCHEMBL6478445 0.81 EGFR (0.47) EGFRRXRAPPARGPPARDPPARA
SCHEMBL8174596 0.81 EGFR (0.41) MAPTRAB9ANPC1SMN1; SMN2EGFR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6150413-A TREATMENT OF DERMATOLOGICAL, RHEUMATIC, RESPIRATORY, CARDIOVASCULAR, BONE AND OPHTHALMOLOGICAL DISORDERS, AS WELL AS MAMMALIAN SKIN AND HAIR CONDITIONS; 4-(4-(BIPHENYL-2-YL)BUT-3-EN-1-YNYL)BENZOIC ACID, FOR EXAMPLE CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES (FR) 2000-11-21 US disclosed