SCHEMBL8180652

SCHEMBL8180652

COC(=O)c1ccc(C#C/C=C/c2ccccc2-c2cccc(Cl)c2)cc1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPK14 Q16539 1/20 0.39
SLC6A3 Q01959 5/20 0.38
EGFR P00533 1/20 0.38
SLC6A2 P23975 1/20 0.38
GABRA5 P31644 1/20 0.37
CHRM1 P11229 1/20 0.37
CHRM3 P20309 1/20 0.37
CDC25A P30304 1/20 0.36
CDC25B P30305 1/20 0.36
MAPT P10636 1/20 0.36
PTPN11 Q06124 1/20 0.36
ALDH1A1 P00352 2/20 0.35
HPGD P15428 2/20 0.35
NPC1 O15118 1/20 0.35
SMN1; SMN2 Q16637 1/20 0.35
PLAU P00749 1/20 0.35
GLA P06280 1/20 0.35
TDP1 Q9NUW8 1/20 0.35
L3MBTL1 Q9Y468 1/20 0.35
SLC6A4 P31645 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8167571 0.88 EGFR (0.41) EGFRCDC25BPTPN11ALDH1A1HPGD
SCHEMBL8180309 0.88 HSD17B10 (0.40) MAPK14EGFRCDC25BMAPTPTPN11
SCHEMBL8166934 0.88 SLC6A4 (0.48) SLC6A3EGFRCDC25ACDC25BMAPT
SCHEMBL8175916 0.88 EGFR (0.46) EGFRCDC25BMAPTPTPN11ALDH1A1
SCHEMBL8167132 0.88 RAB9A (0.44) EGFRMAPTALDH1A1HPGDNPC1
SCHEMBL7930628 0.87 MAP4K4 (0.43) CHRM1CHRM3MAPTNPC1PTGER1
SCHEMBL8175387 0.83 MAPT (0.40) EGFRMAPTNPC1SMN1; SMN2TDP1
SCHEMBL8167327 0.83 TDP1 (0.46) EGFRCDC25BMAPTPTPN11ALDH1A1
SCHEMBL8180152 0.83 CA1 (0.46) EGFRCDC25BPTPN11ALDH1A1HPGD
SCHEMBL8175054 0.82 MAPT (0.44) MAPTALDH1A1NPC1SMN1; SMN2TDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6150413-A TREATMENT OF DERMATOLOGICAL, RHEUMATIC, RESPIRATORY, CARDIOVASCULAR, BONE AND OPHTHALMOLOGICAL DISORDERS, AS WELL AS MAMMALIAN SKIN AND HAIR CONDITIONS; 4-(4-(BIPHENYL-2-YL)BUT-3-EN-1-YNYL)BENZOIC ACID, FOR EXAMPLE CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES (FR) 2000-11-21 US disclosed