Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCB | P05771 | 7/20 | 0.78 |
| ▸ | CDK4 | P11802 | 3/20 | 0.78 |
| ▸ | CCND1 | P24385 | 3/20 | 0.78 |
| ▸ | CDK2 | P24941 | 3/20 | 0.78 |
| ▸ | PRKCA | P17252 | 3/20 | 0.78 |
| ▸ | CCNE2 | O96020 | 2/20 | 0.78 |
| ▸ | PRKACA | P17612 | 2/20 | 0.78 |
| ▸ | PRKACG | P22612 | 2/20 | 0.78 |
| ▸ | PRKACB | P22694 | 2/20 | 0.78 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.78 |
| ▸ | CAMK2D | Q13557 | 2/20 | 0.78 |
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.78 |
| ▸ | ABL1 | P00519 | 2/20 | 0.78 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.78 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.78 |
| ▸ | PRKCG | P05129 | 1/20 | 0.78 |
| ▸ | CDK1 | P06493 | 1/20 | 0.78 |
| ▸ | PIM1 | P11309 | 1/20 | 0.78 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.78 |
| ▸ | PRKCH | P24723 | 1/20 | 0.78 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ro-316233 SCHEMBL624896 | 0.88 | PRKCB (1.00) | PRKCBCDK4CCND1CDK2PRKCA | |
| Ro-316233 SCHEMBL29373011 | 0.88 | PRKCB (1.00) | PRKCBCDK4CCND1CDK2PRKCA | |
| SCHEMBL3148490 | 0.81 | PRKCB (0.84) | PRKCBCDK4CCND1CDK2PRKCA | |
| SCHEMBL2881681 | 0.78 | CDK4 (0.54) | PRKCBCDK4CCND1CDK2PRKCA | |
| SCHEMBL13917970 | 0.77 | PRKCB (0.78) | PRKCBCDK4CCND1CDK2PRKCA | |
| SCHEMBL3908534 | 0.77 | PRKCB (0.78) | PRKCBCDK4CCND1CDK2PRKCA | |
| SCHEMBL6098588 | 0.77 | PRKCB (0.78) | PRKCBCDK4CCND1CDK2PRKCA | |
| SCHEMBL29756414 | 0.77 | PRKCB (0.78) | PRKCBCDK4CCND1CDK2PRKCA | |
| SCHEMBL5333315 | 0.77 | PRKCB (0.78) | PRKCBCDK4CCND1CDK2PRKCA | |
| SCHEMBL6823304 | 0.77 | PRKCB (0.78) | PRKCBCDK4CCND1CDK2PRKCA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE36736-E | Substituted pyrroles | HOFFMAN-LA ROCHE INC. (US) | 2000-06-13 | — | — | US | disclosed |
| EP-0328026-B1 | SUBSTITUTED PYRROLES | F. HOFFMANN-LA ROCHE AG (CH) | 1993-04-28 | — | — | EP | disclosed |
| US-5057614-A | Antiinflammatory, immunology, bronchodilator agents, cardiovascular disorders | HOFFMANN-LA ROCHE INC. (US) | 1991-10-15 | — | — | US | disclosed |
| EP-0328026-A1 | Substituted pyrroles | F. HOFFMANN-LA ROCHE AG (CH) | 1989-08-16 | — | — | EP | disclosed |