SCHEMBL8167267

SCHEMBL8167267

CCc1ccc(N)c(C2CCCC2)c1N

nearest known ligand 0.32

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
NOS3 P29474 2/20 0.32
NOS1 P29475 2/20 0.32
NOS2 P35228 2/20 0.32
POLB P06746 2/20 0.31
HTT P42858 1/20 0.31
ALDH1A1 P00352 1/20 0.30
MAPT P10636 1/20 0.30
PTGS1 P23219 1/20 0.30
PTGS2 P35354 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10430419 0.78 EPHX2 (0.37) POLBHTT
SCHEMBL9722016 0.76 EPHX2 (0.34) NOS3NOS1NOS2HTT
SCHEMBL4303691 0.76 POLB (0.35) POLBALDH1A1PTGS2
SCHEMBL22183231 0.75 CEL (0.38)
SCHEMBL4482096 0.74 TDO2 (0.38) NOS3NOS1NOS2ALDH1A1MAPT
SCHEMBL247757 0.74 TDO2 (0.38) NOS3NOS1NOS2ALDH1A1MAPT
SCHEMBL3692132 0.74 TDO2 (0.38) NOS3NOS1NOS2ALDH1A1MAPT
SCHEMBL27951361 0.73 TDO2 (0.37)
SCHEMBL1498800 0.72 TDO2 (0.39) MAPT
SCHEMBL3428803 0.71 NOS3 (0.31) NOS3NOS1NOS2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2000077062-A1 CLEAR, RESILIENT POLYURETHANE ELASTOMERS UNIROYAL CHEMICAL COMPANY, INC. (US) 2000-12-21 WO disclosed