Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 1/20 | 0.58 |
| ▸ | CA2 | P00918 | 1/20 | 0.58 |
| ▸ | CCR5 | P51681 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.56 |
| ▸ | USP28 | Q96RU2 | 1/20 | 0.56 |
| ▸ | USP25 | Q9UHP3 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 3/20 | 0.55 |
| ▸ | LMNA | P02545 | 3/20 | 0.54 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 3/20 | 0.54 |
| ▸ | MAPT | P10636 | 3/20 | 0.54 |
| ▸ | THRB | P10828 | 3/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | GAA | P10253 | 2/20 | 0.54 |
| ▸ | BLM | P54132 | 2/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.54 |
| ▸ | USP2 | O75604 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6260635 | 0.90 | MAPT (0.61) | CCR5ALDH1A1USP28USP25RAB9A | |
| SCHEMBL8172349 | 0.90 | CCR5 (0.57) | CA1CA2CCR5ALDH1A1USP28 | |
| Sulfuric Acid SCHEMBL6260385 | 0.85 | CCR5 (0.52) | CCR5ALDH1A1USP28USP25RAB9A | |
| SCHEMBL8409537 | 0.84 | CCR5 (0.53) | CCR5ALDH1A1USP28USP25RAB9A | |
| SCHEMBL8324940 | 0.84 | CCR5 (0.53) | CCR5ALDH1A1USP28USP25RAB9A | |
| SCHEMBL9054195 | 0.84 | USP28 (0.58) | CCR5ALDH1A1USP28USP25RAB9A | |
| SCHEMBL8167961 | 0.84 | MRGPRX4 (0.55) | CA1CA2ALDH1A1LMNAHIF1A | |
| SCHEMBL8166853 | 0.84 | STAT3 (0.57) | CA1CA2ALDH1A1HTTLMNA | |
| Sulfuric Acid SCHEMBL6260378 | 0.84 | STAT3 (0.54) | CCR5ALDH1A1USP28USP25RAB9A | |
| SCHEMBL6260379 | 0.84 | CCR5 (0.51) | CCR5ALDH1A1USP28USP25RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1085663-C | Aromatic amino ethers as analgesic agents | ZENECA LTD (GB) | 2002-05-29 | — | — | CN | disclosed |
| CN-1286254-A | Aromatic amino ethers as analgesic agents | ZENECA LTD (GB) | 2001-03-07 | — | — | CN | disclosed |
| EP-0773930-B1 | AROMATIC AMINO ETHERS AS PAIN RELIEVING AGENTS | ZENECA LTD (GB) | 2000-10-11 | — | — | EP | disclosed |
| US-5843942-A | Aromatic amino ethers as pain relieving agents | ZENECA LIMITED (GB) | 1998-12-01 | — | — | US | disclosed |
| CN-1154106-A | Aromatic amino ethers as analgesic agents | ZENECA LTD (GB) | 1997-07-09 | — | — | CN | disclosed |