Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | THRB | P10828 | 1/20 | 0.56 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | FBP1 | P09467 | 13/20 | 0.55 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.52 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18727424 | 0.81 | HDAC6 (0.38) | MAPTFBP1KCNH2MEN1GAA | |
| SCHEMBL21154027 | 0.78 | LMNA (0.56) | LMNACYP1A2MAPTTHRBALOX15 | |
| SCHEMBL10700728 | 0.78 | LMNA (0.56) | LMNACYP1A2MAPTTHRBALOX15 | |
| SCHEMBL8169578 | 0.77 | FBP1 (0.55) | LMNACYP1A2MAPTTHRBALOX15 | |
| SCHEMBL3777315 | 0.76 | KCNH2 (0.63) | LMNACYP1A2MAPTTHRBALOX15 | |
| SCHEMBL6591400 | 0.76 | NPC1 (0.56) | LMNAMAPTALOX15MEN1GAA | |
| SCHEMBL14047971 | 0.75 | FFAR2 (0.60) | LMNACYP1A2MAPTTHRBALOX15 | |
| SCHEMBL7464328 | 0.75 | KDM4E (0.64) | LMNACYP1A2MAPTTHRBALOX15 | |
| SCHEMBL21162595 | 0.74 | FBP1 (0.55) | LMNACYP1A2MAPTTHRBALOX15 | |
| SCHEMBL19899736 | 0.74 | NPC1 (0.60) | LMNACYP1A2MAPTTHRBALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6110933-A | AN ENZYME INHIBITOR TREATING PANCREATITIS, HEPATITIS, CHRONIC RENAL FAILURE, ENDOTOXIN SHOCK, GRAM-NEGATIVE SEPTIC SHOCK, ARTHRITIS, RESPIRATORY DISEASE, HEART DISEASE, ALLERGIC DISEASE, THROMBOSIS, ARTERIOSCLEROSIS, PAIN | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2000-08-29 | — | — | US | disclosed |
| EP-0741697-B1 | AMINO ACID DERIVATIVES AND THEIR USE AS PHOSPHOLIPASE A2 INHIBITORS | FUJISAWA PHARMACEUTICAL CO (JP) | 1999-09-15 | — | — | EP | disclosed |
| EP-0741697-A1 | AMINO ACID DERIVATIVES AND THEIR USE AS PHOSPHOLIPASE A2 INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1996-11-13 | — | — | EP | disclosed |
| WO-1995019959-A1 | AMINO ACID DERIVATIVES AND THEIR USE AS PHOSPHOLIPASE A2 INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1995-07-27 | — | — | WO | disclosed |