Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 2/20 | 0.74 |
| ▸ | HTR3A | P46098 | 2/20 | 0.74 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.74 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.74 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.74 |
| ▸ | HTR2A | P28223 | 1/20 | 0.74 |
| ▸ | HTR2C | P28335 | 1/20 | 0.74 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.74 |
| ▸ | HTR2B | P41595 | 1/20 | 0.74 |
| ▸ | CASP6 | P55212 | 1/20 | 0.72 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.40 |
| ▸ | HTR3B | O95264 | 1/20 | 0.40 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.40 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.40 |
| ▸ | CD44 | P16070 | 1/20 | 0.40 |
| ▸ | DHFR | P00374 | 1/20 | 0.38 |
| ▸ | FNTA | P49354 | 1/20 | 0.38 |
| ▸ | FNTB | P49356 | 1/20 | 0.38 |
| ▸ | PGGT1B | P53609 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Maleic Acid SCHEMBL875 | 0.95 | KCNH2 (0.67) | KCNH2HTR3ACYP1A2CYP3A4ADRA2C | |
| Fumaric Acid SCHEMBL876 | 0.95 | KCNH2 (0.67) | KCNH2HTR3ACYP1A2CYP3A4ADRA2C | |
| Alosetron SCHEMBL29377019 | 0.85 | KCNH2 (1.00) | KCNH2HTR3ACYP1A2CYP3A4ADRA2C | |
| Alosetron SCHEMBL631 | 0.85 | KCNH2 (1.00) | KCNH2HTR3ACYP1A2CYP3A4ADRA2C | |
| SCHEMBL980 | 0.84 | KCNH2 (0.76) | KCNH2HTR3ACYP1A2CYP3A4ADRA2C | |
| Alosetron SCHEMBL29387635 | 0.84 | CASP6 (1.00) | KCNH2HTR3ACYP1A2CYP3A4ADRA2C | |
| Alosetron SCHEMBL806 | 0.84 | CASP6 (1.00) | KCNH2HTR3ACYP1A2CYP3A4ADRA2C | |
| SCHEMBL702 | 0.83 | KCNH2 (0.78) | KCNH2HTR3ACYP1A2CYP3A4ADRA2C | |
| Alosetron SCHEMBL635233 | 0.83 | KCNH2 (0.96) | KCNH2HTR3ACYP1A2CYP3A4ADRA2C | |
| Alosetron SCHEMBL850 | 0.83 | KCNH2 (0.90) | KCNH2HTR3ACYP1A2CYP3A4ADRA2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5360800-A | Tetrahydro-1H-pyrido[4,3-b]indol-1-one derivatives | GLAXO GROUP LIMITED (GB) | 1994-11-01 | — | — | US | claimed |
| EP-0306323-B1 | Lactam derivatives | GLAXO GROUP LTD (GB) | 1994-09-21 | — | — | EP | claimed |
| US-5221687-A | Antidepressants | GLAXO GROUP LIMITED (GB) | 1993-06-22 | — | — | US | claimed |
| US-5360800-A | Tetrahydro-1H-pyrido[4,3-b]indol-1-one derivatives | GLAXO GROUP LIMITED (GB) | 1994-11-01 | — | — | US | disclosed |
| US-5229407-A | Administering to humans or animals for treatment of cognitive disorders | GLAXO GROUP LIMITED (GB) | 1993-07-20 | — | — | US | disclosed |
| US-5225407-A | Cognition activators | GLAXO GROUP LIMITED (GB) | 1993-07-06 | — | — | US | disclosed |
| US-5221687-A | Antidepressants | GLAXO GROUP LIMITED (GB) | 1993-06-22 | — | — | US | disclosed |