Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 1/20 | 0.57 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.57 |
| ▸ | PLCG1 | P19174 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA4 | P22748 | 1/20 | 0.40 |
| ▸ | CA6 | P23280 | 1/20 | 0.40 |
| ▸ | GBA1 | P04062 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.37 |
| ▸ | HTR6 | P50406 | 4/20 | 0.36 |
| ▸ | KDM1A | O60341 | 1/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8558248 | 0.92 | CHRM1 (0.52) | CHRM1CHRM3PLCG1MAPTCA1 | |
| SCHEMBL8557186 | 0.74 | CHRM1 (0.49) | CHRM1CHRM3SLC6A4HTR6KDM1A | |
| SCHEMBL15916256 | 0.73 | PLCG1 (0.60) | PLCG1MAPTCA1CA2CA4 | |
| SCHEMBL6469248 | 0.71 | CHRM1 (0.45) | CHRM1CHRM3CA2GBA1SLC6A4 | |
| SCHEMBL6011594 | 0.70 | CRBN (0.46) | CHRM1CHRM3KMT2A | |
| SCHEMBL8555011 | 0.70 | ALDH1A1 (0.51) | CHRM1CHRM3MAPTHTR6KDM1A | |
| SCHEMBL6011463 | 0.70 | CHRM1 (0.44) | CHRM1CHRM3CA1CA2CA4 | |
| SCHEMBL6011372 | 0.70 | CHRM1 (0.44) | CHRM1CHRM3CA2KDM1AKMT2A | |
| SCHEMBL15917691 | 0.70 | MAPT (0.74) | PLCG1MAPTCA1CA2CA4 | |
| SCHEMBL6469254 | 0.70 | CHRM1 (0.44) | CHRM1CHRM3CA1CA2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6114328-A | ANTICOAGULANTS; BLOOD DISORDERS | DUPONT PHARMACEUTICALS COMPANY (US) | 2000-09-05 | — | — | US | disclosed |
| US-5849736-A | Isoxazoline and isoxazole fibrinogen receptor antagonists | THE DUPONT MERCK PHARMACEUTICAL COMPANY (US) | 1998-12-15 | — | — | US | disclosed |
| EP-0832076-A1 | NOVEL ISOXAZOLINE AND ISOXAZOLE FIBRINOGEN RECEPTOR ANTAGONISTS | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1998-04-01 | — | — | EP | disclosed |