Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNP | P00491 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | GDA | Q9Y2T3 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.33 |
| ▸ | XDH | P47989 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | ALB | P02768 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.30 |
| ▸ | BLM | P54132 | 1/20 | 0.30 |
| ▸ | TYMP | P19971 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8159669 | 0.84 | TDP1 (0.39) | PNPALDH1A1KMT2APOLB | |
| SCHEMBL2352519 | 0.84 | PNP (0.43) | PNPGDAXDHALDH1A1MEN1 | |
| SCHEMBL10947288 | 0.78 | CYP3A4 (0.38) | PNPMAPK1GDAHPGDALDH1A1 | |
| SCHEMBL5315626 | 0.77 | PNP (0.38) | PNPGDAXDHALDH1A1MEN1 | |
| SCHEMBL1375443 | 0.75 | XDH (0.54) | PNPXDHALDH1A1MEN1KMT2A | |
| SCHEMBL160199 | 0.72 | GDA (0.37) | PNPGDAALDH1A1 | |
| SCHEMBL28135346 | 0.71 | PNP (0.41) | PNPGDAXDHALDH1A1MEN1 | |
| SCHEMBL4560085 | 0.71 | GDA (0.53) | PNPMAPK1GDAXDHALDH1A1 | |
| SCHEMBL10998 | 0.71 | GDA (0.53) | PNPMAPK1GDAXDHALDH1A1 | |
| SCHEMBL21682417 | 0.70 | KMT2A (0.37) | PNPGDAALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6107078-A | SYNTHETIC HAMMERHEAD RIBOZYMES WITH SPECIFIC CONFORMATIONS; DIAGNOSTIC OR THERAPEUTIC AGENTS | GENE SHEARS PTY LIMITED (AU) | 2000-08-22 | — | — | US | disclosed |
| US-6004806-A | NUCLEOTIDE SEQUENCE OF BIOCATALYSTS WHICH HYBRIDIZE TO TARGET RNA TO BE CLEAVED; FOR DIAGNOSTIC OR THERAPEUTIC AGENTS; GENE THERAPY | COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANIZATION (AU) | 1999-12-21 | — | — | US | disclosed |
| US-5998193-A | GENETIC ENGINEERING | GENE SHEARS PTY., LTD. (AU) | 1999-12-07 | — | — | US | disclosed |
| EP-0808322-A1 | RIBOZYMES WITH OPTIMIZED HYBRIDIZING ARMS, STEMS, AND LOOPS, tRNA EMBEDDED RIBOZYMES AND COMPOSITIONS THEREOF | Gene Shears Pty Limited (AU) | 1997-11-26 | — | — | EP | disclosed |
| WO-1996000232-A1 | RIBOZYMES WITH OPTIMIZED HYBRIDIZING ARMS, STEMS, AND LOOPS, tRNA EMBEDDED RIBOZYMES AND COMPOSITIONS THEREOF | GENE SHEARS PTY. LTD. (AU) | 1996-01-04 | — | — | WO | disclosed |