SCHEMBL1375443

SCHEMBL1375443

Cc1cn(-n2cnc3c(=O)[nH]c(N)nc32)c(=O)[nH]c1=O

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
XDH P47989 8/20 0.54
PNP P00491 3/20 0.44
TK1 P04183 2/20 0.44
MEN1 O00255 2/20 0.44
KMT2A Q03164 2/20 0.44
BLM P54132 2/20 0.43
USP2 O75604 1/20 0.43
TSHR P16473 1/20 0.43
EDNRA P25101 1/20 0.43
HTR2A P28223 1/20 0.43
RECQL P46063 1/20 0.43
HBB P68871 1/20 0.43
HSD17B10 Q99714 1/20 0.43
ALDH1A1 P00352 1/20 0.42
LMNA P02545 1/20 0.42
CYP3A4 P08684 1/20 0.42
NFKB1 P19838 1/20 0.42
VCP P55072 1/20 0.42
SMN1; SMN2 Q16637 1/20 0.42
HIF1A Q16665 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL986800 0.84 XDH (0.60) XDHPNPTK1MEN1KMT2A
SCHEMBL7513539 0.84 XDH (0.51) XDHPNPTK1MEN1KMT2A
SCHEMBL4621403 0.83 XDH (0.50) XDHPNPTK1MEN1KMT2A
SCHEMBL15005119 0.83 XDH (0.59) XDHPNPTK1MEN1KMT2A
SCHEMBL3474052 0.79 ADORA2A (0.44) LMNASMN1; SMN2
SCHEMBL4426345 0.77 XDH (0.54) XDHPNPTK1MEN1KMT2A
SCHEMBL72147 0.77 XDH (0.50) XDHPNPTK1MEN1KMT2A
SCHEMBL8171998 0.75 PNP (0.35) XDHPNPMEN1KMT2ABLM
SCHEMBL1825531 0.75 XDH (0.51) XDHPNPTK1MEN1KMT2A
SCHEMBL1831279 0.74 XDH (0.50) XDHPNPTK1MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 59 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240055073-A1 SAMPLE CONTAMINATION DETECTION OF CONTAMINATED FRAGMENTS WITH CPG-SNP CONTAMINATION MARKERS GRAIL, LLC 2024-02-15 US claimed
WO-2024025831-A1 SAMPLE CONTAMINATION DETECTION OF CONTAMINATED FRAGMENTS WITH CPG-SNP CONTAMINATION MARKERS GRAIL, LLC (US) 2024-02-01 WO claimed
US-11788141-B2 MVD as epigenetic marker for the identification of immune cells, in particular CD56+ NK cells PRECISION FOR MEDICINE GMBH (DE) 2023-10-17 US claimed
US-11667973-B2 Endosialin (CD248) as epigenetic marker for the identification of immune cells, in particular naïve CD8+ t-cells PRECISION FOR MEDICINE GMBH (DE) 2023-06-06 US claimed
WO-2020185681-A2 COMPOSITIONS AND METHODS RELATED TO GOLD-MEDIATED NUCLEIC ACID HYBRIDIZATION THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2020-09-17 WO claimed
EP-2189526-B1 ANTIBODY BINDING SPECIFICALLY TO TDP-43 AGGREGATE TOKYO METROPOLITAN INST MEDICAL SCIENCE (JP) 2013-09-04 EP claimed
US-7521178-B1 Method for synthesizing DNA TAKARA BIO INC. (JP) 2009-04-21 US claimed
US-20020142315-A1 DNA marker for cattle growth THE CURATORS OF THE UNIVERSITY OF MISSOURI 2002-10-03 US claimed
EP-4381072-A1 GENOME EDITING COMPOSITIONS AND METHODS FOR TREATMENT OF MYOTONIC DYSTROPHY Prime Medicine, Inc. (US) 2024-06-12 EP disclosed
US-20240142451-A1 METHODS FOR CHARACTERIZING THE IMMUNE RESPONSE OF A SUBJECT TO A DENGUE VIRUS COMPOSITION TAKEDA VACCINES INC (US) 2024-05-02 US disclosed
WO-2024086605-A1 DENGUE VACCINE FORMULATION TAKEDA VACCINES, INC. (US) 2024-04-25 WO disclosed
EP-4356925-A2 DENGUE VACCINE FORMULATION Takeda Vaccines, Inc. (US) 2024-04-24 EP disclosed
WO-2024081863-A1 USE OF DENGUE VACCINE IN PREGNANT AND/OR BREASTFEEDING SUBJECTS TAKEDA VACCINES, INC. (US) 2024-04-18 WO disclosed
US-20240055073-A1 SAMPLE CONTAMINATION DETECTION OF CONTAMINATED FRAGMENTS WITH CPG-SNP CONTAMINATION MARKERS GRAIL, LLC 2024-02-15 US disclosed
US-20040002155-A1 Endonuclease VII cloning method STRATAGENE 2004-01-01 US disclosed
US-20020142315-A1 DNA marker for cattle growth THE CURATORS OF THE UNIVERSITY OF MISSOURI 2002-10-03 US disclosed
EP-0639200-A1 METHODS AND REAGENTS FOR CLEAVING AND DEPROTECTING OLIGONUCLEOTIDES BECKMAN INSTRUMENTS, INC. (US) 1995-02-22 EP disclosed
WO-1993022329-A1 METHODS AND REAGENTS FOR CLEAVING AND DEPROTECTING OLIGONUCLEOTIDES BECKMAN INSTRUMENTS, INC. (US) 1993-11-11 WO disclosed
EP-0094797-A2 Novel cloning vehicles for polypeptide expression in microbial hosts THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK (US) 1983-11-23 EP disclosed
EP-0055942-A2 Plasmid cloning vehicles THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK (US) 1982-07-14 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11788141-B2 MVD as epigenetic marker for the identification of immune cells, in particular CD56+ NK cells MVD, ENTPD5, ENTPD1 XDH 4591/4885PNP 488/4885TK1 65/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.