Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 5/20 | 0.74 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.56 |
| ▸ | MEN1 | O00255 | 4/20 | 0.56 |
| ▸ | TTR | P02766 | 1/20 | 0.56 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.56 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.50 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | GLA | P06280 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.46 |
| ▸ | NAT1 | P18440 | 3/20 | 0.46 |
| ▸ | MYC | P01106 | 1/20 | 0.43 |
| ▸ | MAX | P61244 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8173766 | 1.00 | PIM1 (0.74) | PIM1KMT2AMEN1TTRAKR1B1 | |
| SCHEMBL1247506 | 0.85 | PIM1 (1.00) | PIM1KMT2AMEN1TTRAKR1B1 | |
| SCHEMBL1247507 | 0.85 | PIM1 (1.00) | PIM1KMT2AMEN1TTRAKR1B1 | |
| SCHEMBL8173296 | 0.82 | PIM1 (0.51) | PIM1KMT2AMEN1ALDH1A1MAPT | |
| SCHEMBL8173297 | 0.82 | PIM1 (0.51) | PIM1KMT2AMEN1ALDH1A1MAPT | |
| SCHEMBL8171863 | 0.77 | PIM1 (0.46) | PIM1KMT2AMEN1ALDH1A1MAPT | |
| SCHEMBL8171866 | 0.77 | PIM1 (0.46) | PIM1KMT2AMEN1ALDH1A1MAPT | |
| SCHEMBL8192006 | 0.74 | NAT1 (0.74) | PIM1KMT2AMEN1ALDH1A1MAPT | |
| SCHEMBL8192000 | 0.74 | NAT1 (0.74) | PIM1KMT2AMEN1ALDH1A1MAPT | |
| SCHEMBL8176867 | 0.73 | TDP1 (0.77) | PIM1KMT2AMEN1ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2000018748-A1 | RHODANINE DERIVATIVES FOR THE TREATMENT AND PREVENTION OF METABOLIC BONE DISORDERS | ROCHE DIAGNOSTICS GMBH (DE) | 2000-04-06 | — | — | WO | disclosed |