Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | RAB9A | P51151 | 3/20 | 0.33 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.33 |
| ▸ | CES2 | O00748 | 1/20 | 0.33 |
| ▸ | CES1 | P23141 | 1/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | SYK | P43405 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8188784 | 0.73 | ALDH1A1 (0.52) | HPGDHTTALDH1A1L3MBTL1KDM4E | |
| SCHEMBL8670078 | 0.72 | HTT (0.35) | GAAHPGDHTTALDH1A1ALOX12 | |
| SCHEMBL8173645 | 0.71 | RIPK1 (0.38) | HPGDHTTALDH1A1LMNAHSP90AB1 | |
| SCHEMBL8173414 | 0.70 | HTT (0.38) | GAAHTTALDH1A1ALOX12LMNA | |
| SCHEMBL23317645 | 0.69 | HTT (0.57) | GAAHPGDHTTALDH1A1ALOX12 | |
| SCHEMBL8677242 | 0.68 | ADORA1 (0.32) | ALDH1A1ALOX12LMNAL3MBTL1KDM4E | |
| SCHEMBL14590338 | 0.67 | HTT (0.47) | GAAHTTALDH1A1ALOX12LMNA | |
| SCHEMBL8782474 | 0.66 | HTT (0.42) | GAAHTTALDH1A1ALOX12LMNA | |
| SCHEMBL78472 | 0.66 | HTT (0.35) | GAAHTTALDH1A1L3MBTL1RIPK1 | |
| SCHEMBL19768974 | 0.66 | RECQL (0.40) | GAAHPGDALDH1A1KDM4ECES2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6043284-A | ACYL COENZYME A: CHOLESTEROL ACYLTRANSFERASE (ACAT) INHIBITORS | GLAXO WELLCOME INC. (US) | 2000-03-28 | — | — | US | disclosed |