Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1D | P25100 | 1/20 | 0.84 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.84 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.84 |
| ▸ | CA12 | O43570 | 2/20 | 0.42 |
| ▸ | CA2 | P00918 | 2/20 | 0.42 |
| ▸ | CA9 | Q16790 | 2/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | PRCP | P42785 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.37 |
| ▸ | CCR5 | P51681 | 2/20 | 0.36 |
| ▸ | CCR3 | P51677 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.36 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.36 |
| ▸ | CDK9 | P50750 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8172876 | 0.93 | ADRA1B (0.80) | ADRA1DADRA1AADRA1BCA12CA2 | |
| SCHEMBL8177368 | 0.91 | ADRA1D (1.00) | ADRA1DADRA1AADRA1BCA12CA2 | |
| SCHEMBL8181575 | 0.87 | ADRA1D (0.75) | ADRA1DADRA1AADRA1BCA12CA2 | |
| SCHEMBL8174189 | 0.85 | ADRA1D (0.89) | ADRA1DADRA1AADRA1BCA12CA2 | |
| SCHEMBL8174151 | 0.84 | ADRA1D (0.72) | ADRA1DADRA1AADRA1BCA12CA2 | |
| Hydrochloric Acid SCHEMBL8174041 | 0.84 | ADRA1D (0.87) | ADRA1DADRA1AADRA1BCA12CA2 | |
| SCHEMBL8175556 | 0.83 | ADRA1D (0.66) | ADRA1DADRA1AADRA1BPRCPHTR2A | |
| SCHEMBL8172981 | 0.82 | ADRA1D (0.83) | ADRA1DADRA1AADRA1BCA12CA2 | |
| SCHEMBL8170068 | 0.81 | ADRA1D (0.83) | ADRA1DADRA1AADRA1BCA12CA2 | |
| SCHEMBL8173553 | 0.78 | ADRA1D (0.77) | ADRA1DADRA1AADRA1BHTR2AABCB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6090825-A | Oxazole derivatives as antagonists of alpha 1C andrenergic receptors | GLAXO WELLCOME INC. (US) | 2000-07-18 | — | — | US | claimed |
| EP-0793658-A1 | OXAZOLE DERIVATIVES AS ANTAGONISTS OF ALPHA-1C ADRENERGIC RECEPTORS | GLAXO WELLCOME INC. (US) | 1997-09-10 | — | — | EP | claimed |
| WO-1996016049-A1 | OXAZOLE DERIVATIVES AS ANTAGONISTS OF α-1C ADRENERGIC RECEPTORS | GLAXO WELLCOME INC. (US) | 1996-05-30 | — | — | WO | claimed |
| US-6090825-A | Oxazole derivatives as antagonists of alpha 1C andrenergic receptors | GLAXO WELLCOME INC. (US) | 2000-07-18 | — | — | US | disclosed |