Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1D | P25100 | 1/20 | 0.75 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.75 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.75 |
| ▸ | CA12 | O43570 | 3/20 | 0.41 |
| ▸ | CA2 | P00918 | 3/20 | 0.41 |
| ▸ | CA9 | Q16790 | 3/20 | 0.41 |
| ▸ | CA1 | P00915 | 2/20 | 0.40 |
| ▸ | HRH1 | P35367 | 3/20 | 0.38 |
| ▸ | SSTR5 | P35346 | 2/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | EBP | Q15125 | 2/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.36 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.36 |
| ▸ | BCHE | P06276 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | CA4 | P22748 | 1/20 | 0.36 |
| ▸ | CA5A | P35218 | 1/20 | 0.36 |
| ▸ | CA7 | P43166 | 1/20 | 0.36 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.36 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8174151 | 0.93 | ADRA1D (0.72) | ADRA1DADRA1AADRA1BCA12CA2 | |
| SCHEMBL8174189 | 0.92 | ADRA1D (0.89) | ADRA1DADRA1AADRA1BCA12CA2 | |
| SCHEMBL8173563 | 0.89 | ADRA1D (0.61) | ADRA1DADRA1AADRA1BHRH1SSTR5 | |
| SCHEMBL8174249 | 0.87 | ADRA1D (0.84) | ADRA1DADRA1AADRA1BCA12CA2 | |
| SCHEMBL8177368 | 0.86 | ADRA1D (1.00) | ADRA1DADRA1AADRA1BCA12CA2 | |
| Hydrochloric Acid SCHEMBL8174041 | 0.85 | ADRA1D (0.87) | ADRA1DADRA1AADRA1BCA12CA2 | |
| SCHEMBL8172876 | 0.84 | ADRA1B (0.80) | ADRA1DADRA1AADRA1BCA12CA2 | |
| SCHEMBL8174996 | 0.83 | ADRA1D (0.52) | ADRA1DADRA1AADRA1BKCNH2SIGMAR1 | |
| SCHEMBL8166282 | 0.81 | CA2 (0.62) | ADRA1DADRA1AADRA1BCA12CA2 | |
| SCHEMBL8172981 | 0.80 | ADRA1D (0.83) | ADRA1DADRA1AADRA1BCA12CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6090825-A | Oxazole derivatives as antagonists of alpha 1C andrenergic receptors | GLAXO WELLCOME INC. (US) | 2000-07-18 | — | — | US | claimed |
| EP-0793658-A1 | OXAZOLE DERIVATIVES AS ANTAGONISTS OF ALPHA-1C ADRENERGIC RECEPTORS | GLAXO WELLCOME INC. (US) | 1997-09-10 | — | — | EP | claimed |
| WO-1996016049-A1 | OXAZOLE DERIVATIVES AS ANTAGONISTS OF α-1C ADRENERGIC RECEPTORS | GLAXO WELLCOME INC. (US) | 1996-05-30 | — | — | WO | claimed |