Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1D | P25100 | 1/20 | 0.52 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.52 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.52 |
| ▸ | CASP6 | P55212 | 1/20 | 0.37 |
| ▸ | MPO | P05164 | 1/20 | 0.37 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.36 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 5/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 5/20 | 0.35 |
| ▸ | HTR1A | P08908 | 4/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.35 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.35 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.35 |
| ▸ | RAF1 | P04049 | 1/20 | 0.35 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.35 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | HTR2B | P41595 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8173485 | 0.99 | ADRA1D (0.51) | ADRA1DADRA1AADRA1BCASP6MPO | |
| SCHEMBL8180362 | 0.91 | ADRA1D (0.44) | ADRA1DADRA1AADRA1BCASP6SLC6A2 | |
| SCHEMBL8173521 | 0.88 | ADRA1D (0.53) | ADRA1DADRA1AADRA1B | |
| SCHEMBL8166843 | 0.85 | ADRA1D (0.42) | ADRA1DADRA1AADRA1BCASP6MPO | |
| Trifluoroacetic Acid SCHEMBL8166220 | 0.85 | ADRA1D (0.42) | ADRA1DADRA1AADRA1BCASP6 | |
| SCHEMBL8174924 | 0.84 | ADRA1D (0.41) | ADRA1DADRA1AADRA1BCASP6MPO | |
| SCHEMBL8179453 | 0.84 | ADRA1D (0.39) | ADRA1DADRA1AADRA1BCASP6MPO | |
| SCHEMBL8166794 | 0.81 | ADRA1D (0.57) | ADRA1DADRA1AADRA1BMAPK14MAPK11 | |
| SCHEMBL8166964 | 0.81 | ADRA1D (0.59) | ADRA1DADRA1AADRA1BMAPK14 | |
| SCHEMBL8178561 | 0.80 | MPO (0.41) | ADRA1DADRA1AADRA1BCASP6MPO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6090825-A | Oxazole derivatives as antagonists of alpha 1C andrenergic receptors | GLAXO WELLCOME INC. (US) | 2000-07-18 | — | — | US | disclosed |
| EP-0793658-A1 | OXAZOLE DERIVATIVES AS ANTAGONISTS OF ALPHA-1C ADRENERGIC RECEPTORS | GLAXO WELLCOME INC. (US) | 1997-09-10 | — | — | EP | disclosed |
| WO-1996016049-A1 | OXAZOLE DERIVATIVES AS ANTAGONISTS OF α-1C ADRENERGIC RECEPTORS | GLAXO WELLCOME INC. (US) | 1996-05-30 | — | — | WO | disclosed |