Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MPO | P05164 | 1/20 | 0.41 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.41 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.41 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.40 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.39 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.39 |
| ▸ | RAF1 | P04049 | 1/20 | 0.39 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.39 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | HTR2B | P41595 | 1/20 | 0.37 |
| ▸ | CASP6 | P55212 | 1/20 | 0.37 |
| ▸ | PLAT | P00750 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | USP7 | Q93009 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8174924 | 0.86 | ADRA1D (0.41) | MPOMKNK1MKNK2MAPK11MAPK14 | |
| SCHEMBL8174657 | 0.86 | PRKAA2 (0.41) | PRKAA2LMNAALOX15TSHRMAPK1 | |
| SCHEMBL8174317 | 0.84 | USP7 (0.40) | MPOMKNK1MKNK2PRKAA2MAPK11 | |
| SCHEMBL8174451 | 0.80 | ADRA1D (0.52) | MPOMKNK1MKNK2MAPK11MAPK14 | |
| SCHEMBL3089251 | 0.80 | NR4A2 (0.45) | MPOMKNK1MKNK2MAPK11MAPK14 | |
| SCHEMBL8179453 | 0.79 | ADRA1D (0.39) | MPOMKNK1MKNK2MAPK11MAPK14 | |
| Hydrochloric Acid SCHEMBL8173485 | 0.79 | ADRA1D (0.51) | MPOMKNK1MKNK2MAPK11MAPK14 | |
| SCHEMBL8174185 | 0.79 | LMNA (0.45) | MAPK11MAPK14HTR2BLMNAALOX15 | |
| SCHEMBL8174322 | 0.79 | USP7 (0.39) | MPOMKNK1MKNK2PRKAA2MAPK11 | |
| SCHEMBL3100353 | 0.76 | MAPK14 (0.44) | MPOMKNK1MKNK2MAPK11MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6090825-A | Oxazole derivatives as antagonists of alpha 1C andrenergic receptors | GLAXO WELLCOME INC. (US) | 2000-07-18 | — | — | US | disclosed |
| EP-0793658-A1 | OXAZOLE DERIVATIVES AS ANTAGONISTS OF ALPHA-1C ADRENERGIC RECEPTORS | GLAXO WELLCOME INC. (US) | 1997-09-10 | — | — | EP | disclosed |
| WO-1996016049-A1 | OXAZOLE DERIVATIVES AS ANTAGONISTS OF α-1C ADRENERGIC RECEPTORS | GLAXO WELLCOME INC. (US) | 1996-05-30 | — | — | WO | disclosed |