Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PAX8 | Q06710 | 1/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.32 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.32 |
| ▸ | HKDC1 | Q2TB90 | 2/20 | 0.32 |
| ▸ | PLAU | P00749 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.31 |
| ▸ | RELA | Q04206 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL811295 | 1.00 | PAX8 (0.35) | PAX8HSP90AA1MEN1KMT2AATM | |
| Hydrochloric Acid SCHEMBL7185143 | 0.97 | PAX8 (0.35) | PAX8HSP90AA1MEN1KMT2AATM | |
| Hydrochloric Acid SCHEMBL7182233 | 0.97 | PAX8 (0.35) | PAX8HSP90AA1MEN1KMT2AATM | |
| Hydrochloric Acid SCHEMBL7175041 | 0.97 | PAX8 (0.35) | PAX8HSP90AA1MEN1KMT2AATM | |
| Hydrochloric Acid SCHEMBL5693547 | 0.97 | PAX8 (0.35) | PAX8HSP90AA1MEN1KMT2AATM | |
| Hydrochloric Acid SCHEMBL7177207 | 0.97 | PAX8 (0.35) | PAX8HSP90AA1MEN1KMT2AATM | |
| Hydrochloric Acid SCHEMBL7176154 | 0.97 | PAX8 (0.35) | PAX8HSP90AA1MEN1KMT2AATM | |
| Hydrochloric Acid SCHEMBL7174397 | 0.97 | PAX8 (0.35) | PAX8HSP90AA1MEN1KMT2AATM | |
| SCHEMBL453478 | 0.97 | HSP90AA1 (0.36) | PAX8HSP90AA1MEN1KMT2AATM | |
| SCHEMBL453477 | 0.97 | HSP90AA1 (0.36) | PAX8HSP90AA1MEN1KMT2AATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 61 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10392455-B2 | Process for controlling the polymer composition of an ethylene copolymer obtained by a catalyst system comprising a transition metal catalyst component and a Ziegler catalyst component | BASELL POLYOLEFINE GMBH (DE) | 2019-08-27 | — | — | US | disclosed |
| EP-1943281-B1 | HYBRID CATALYST SYSTEMS SUPPORTED ON MAGNESIUM HALIDE | BASELL POLYOLEFINE GMBH (DE) | 2017-09-20 | — | — | EP | disclosed |
| EP-2328968-B1 | POLYETHYLENE FOR INJECTION MOLDINGS | BASELL POLYOLEFINE GMBH (DE) | 2017-05-03 | — | — | EP | disclosed |
| US-9273168-B2 | Polyethylene for rotomoulding | BASELL POLYOLEFINE GMBH (DE) | 2016-03-01 | — | — | US | disclosed |
| US-9090761-B2 | Polyethylene for injection moldings | BASELL POLYOLEFINE GMBH (DE) | 2015-07-28 | — | — | US | disclosed |
| US-8957158-B2 | Impact resistant LLDPE composition and films made thereof | BASELL POLYOLEFINE GMBH (DE) | 2015-02-17 | — | — | US | disclosed |
| EP-2655445-B1 | PROCESS FOR CONTROLLING THE RELATIVE ACTIVITY OF ACTIVE CENTERS OF CATALYST SYSTEMS COMPRISING AT LEAST ONE LATE TRANSITION METAL CATALYST COMPONENT AND AT LEAST ONE ZIEGLER CATALYST COMPONENT | BASELL POLYOLEFINE GMBH (DE) | 2014-11-26 | — | — | EP | disclosed |
| US-20140329978-A1 | PROCESS FOR CONTROLLING THE POLYMER COMPOSITION OF AN ETHYLENE COPOLYMER OBTAINED BY A CATALYST SYSTEM COMPRISING A TRANSITION METAL CATALYST COMPONENT AND A ZIEGLER CATALYST COMPONENT | BASELL POLYOLEFINE GMBH (DE) | 2014-11-06 | — | — | US | disclosed |
| US-8865834-B2 | Adhesive polymer composition | BASELL POLYOLEFINE GMBH (DE) | 2014-10-21 | — | — | US | disclosed |
| US-8846188-B2 | Impact resistant LLDPE composition and films made thereof | Basell Poliolefine GmbH (DE) | 2014-09-30 | — | — | US | disclosed |
| EP-1753794-B1 | POLYETHYLENE AND CATALYST COMPOSITION FOR ITS PREPARATION | BASELL POLYOLEFINE GMBH (DE) | 2008-06-04 | — | — | EP | disclosed |
| US-7348388-B2 | Copolymers of olefins and vinyl- and allylsilanes | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 2008-03-25 | — | — | US | disclosed |
| US-20070255033-A1 | Polyethylene for Injection Moldings | BASELL POYOLEFINE GMBH (DE) | 2007-11-01 | — | — | US | disclosed |
| US-20070213205-A1 | Polyethylene and Catalyst Composition for its Preparation | BASELL POLYOLEFINE GMBH (DE) | 2007-09-13 | — | — | US | disclosed |
| EP-1123321-B1 | SUPPORTED BIDENTATE AND TRIDENTATE CATALYST COMPOSITIONS AND OLEFIN POLYMERIZATION USING SAME | GRACE W R & CO (US) | 2006-12-20 | — | — | EP | disclosed |
| EP-1448628-A2 | COPOLYMERS OF OLEFINS AND VINYL- AND ALLYLSILANES | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 2004-08-25 | — | — | EP | disclosed |
| EP-1367069-A1 | Process for homo-or copolymerization of conjugated diens | DOW GLOBAL TECHNOLOGIES INC. (US) | 2003-12-03 | — | — | EP | disclosed |
| US-20030212226-A1 | Copolymers of olefins and vinyl- and allylsilanes | E. I. DU PONT DE NEMOURS AND COMPANY | 2003-11-13 | — | — | US | disclosed |
| WO-2003044066-A2 | COPOLYMERS OF OLEFINS AND VINYL- AND ALLYLSILANES | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 2003-05-30 | — | — | WO | disclosed |
| US-6184171-B1 | CATALYST COMPOSITION COMPRISES AN ANIONIC METALLOID SILANE MODIFIED INORGANIC OXIDE AND THE CATIONIC REMNANT OF A TRANSITION METAL BIDENTATE OR TRIDENTATE COMPOUND | W.R. GRACE & CO. -CONN | 2001-02-06 | — | — | US | disclosed |